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Pregled bibliografske jedinice broj: 1074270

Impact of surface functionalization on the toxicity and antimicrobial effects of selenium nanoparticles considering different routes of entry


Galić, Emerik; Ilić, Krunoslav; Hartl, Sonja; Tetyczka, Carolin; Kasemets, Kaja; Kurvet, Imbi; Milić, Mirta; Barbir, Rinea; Pem, Barbara; Erceg, Ina et al.
Impact of surface functionalization on the toxicity and antimicrobial effects of selenium nanoparticles considering different routes of entry // Food and chemical toxicology, 144 (2020), 111621, 11 doi:10.1016/j.fct.2020.111621 (međunarodna recenzija, članak, znanstveni)


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Naslov
Impact of surface functionalization on the toxicity and antimicrobial effects of selenium nanoparticles considering different routes of entry

Autori
Galić, Emerik ; Ilić, Krunoslav ; Hartl, Sonja ; Tetyczka, Carolin ; Kasemets, Kaja ; Kurvet, Imbi ; Milić, Mirta ; Barbir, Rinea ; Pem, Barbara ; Erceg, Ina ; Dutour Sikirić, V Pavičić, Ivan ; Roblegg, Eva ; Kahru, Anne ; Vinković Vrček, Ivana

Izvornik
Food and chemical toxicology (0278-6915) 144 (2020); 111621, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antimicrobials ; medical industry ; food industry ; nanomaterials safety

Sažetak
Selenium nanoparticles (SeNPs) were first designed as nutritional supplements, but they are attractive also for use in diagnostic and therapeutic systems owing to their biocompatibility and protective effects. This study aimed to examine if different SeNPs stabilization strategies affect their (i) antimicrobial activity against bacteria Escherichia coli and Staphylococcus aureus and yeast Saccharomyces cerevisiae and (ii) toxicity to human cells of different biological barriers i.e., skin, oral and intestinal mucosa. For surface stabilization, polyvinylpyrrolidone (PVP), poly-L-lysine (PLL) and polyacrylic acid (PAA) were used rendering neutral, positively and negatively charged SeNPs, respectively. The SeNPs (primary size ∼80 nm) showed toxic effects in human cells in vitro and in bacteria S. aureus, but not in E. coli and yeast S. cerevisiae. Toxicity of SeNPs (24 h IC50) ranged from 1.4 to >100 mg Se/L, depending on surface functionalization (PLL>PAA>PVP) and was not caused by ionic Se. At subtoxic concentrations, all SeNPs were taken up by all human cell types, induced oxidative stress response and demonstrated genotoxicity. As the safety profile of SeNPs was dependent not only on target cells (mammalian cells, bacteria, yeast) but also on surface functionalization, these aspects should be considered during development of novel SeNPs-based biomedical products.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-DOK-2018-01-8860
HRZZ-DOK-2018-09-1298
HRZZ-IP-2018-01-8119 - Application of Nanobiotechnology for Nutritional Supplementation with Selenium (Tomislav Vinković, )
HRZZ-PZS-2019-02-4323

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Sveučilište J. J. Strossmayera u Osijeku

Citiraj ovu publikaciju

Galić, Emerik; Ilić, Krunoslav; Hartl, Sonja; Tetyczka, Carolin; Kasemets, Kaja; Kurvet, Imbi; Milić, Mirta; Barbir, Rinea; Pem, Barbara; Erceg, Ina et al.
Impact of surface functionalization on the toxicity and antimicrobial effects of selenium nanoparticles considering different routes of entry // Food and chemical toxicology, 144 (2020), 111621, 11 doi:10.1016/j.fct.2020.111621 (međunarodna recenzija, članak, znanstveni)
Galić, E., Ilić, K., Hartl, S., Tetyczka, C., Kasemets, K., Kurvet, I., Milić, M., Barbir, R., Pem, B. & Erceg, I. (2020) Impact of surface functionalization on the toxicity and antimicrobial effects of selenium nanoparticles considering different routes of entry. Food and chemical toxicology, 144, 111621, 11 doi:10.1016/j.fct.2020.111621.
@article{article, year = {2020}, pages = {11}, DOI = {10.1016/j.fct.2020.111621}, chapter = {111621}, keywords = {antimicrobials, medical industry, food industry, nanomaterials safety}, journal = {Food and chemical toxicology}, doi = {10.1016/j.fct.2020.111621}, volume = {144}, issn = {0278-6915}, title = {Impact of surface functionalization on the toxicity and antimicrobial effects of selenium nanoparticles considering different routes of entry}, keyword = {antimicrobials, medical industry, food industry, nanomaterials safety}, chapternumber = {111621} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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