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Pregled bibliografske jedinice broj: 1074012

Importance of genetic polymorphisms in liver transplantation outcomes


Kelava, Tomislav; Turcic, Petra; Markotic, Antonio; Ostojic, Ana; Sisl, Dino; Mrzljak, Anna
Importance of genetic polymorphisms in liver transplantation outcomes // World Journal of Gastroenterology, 26 (2020), 12; 1273-1285 doi:10.3748/wjg.v26.i12.1273 (međunarodna recenzija, pregledni rad, ostalo)


CROSBI ID: 1074012 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Importance of genetic polymorphisms in liver transplantation outcomes

Autori
Kelava, Tomislav ; Turcic, Petra ; Markotic, Antonio ; Ostojic, Ana ; Sisl, Dino ; Mrzljak, Anna

Izvornik
World Journal of Gastroenterology (1007-9327) 26 (2020), 12; 1273-1285

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, ostalo

Ključne riječi
Acute rejection ; Hepatocellular carcinoma ; Liver transplantation ; New-onset diabetes mellitus ; Non-alcoholic fatty liver disease ; Single nucleotide polymorphisms ; Tacrolimus.

Sažetak
Although, liver transplantation serves as the only curative treatment for patients with end- stage liver diseases, it is burdened with complications, which affect survival rates. In addition to clinical risk factors, contribution of recipient and donor genetic prognostic markers has been extensively studied in order to reduce the burden and improve the outcomes. Determination of single nucleotide polymorphisms (SNPs) is one of the most important tools in development of personalized transplant approach. To provide a better insight in recent developments, we review the studies published in the last three years that investigated an association of recipient or donor SNPs with most common issues in liver transplantation: Acute cellular rejection, development of new-onset diabetes mellitus and non-alcoholic fatty liver disease, hepatocellular carcinoma recurrence, and tacrolimus concentration variability. Reviewed studies confirmed previously established SNP prognostic factors, such as PNPLA3 rs738409 for non-alcoholic fatty liver disease development, or the role of CYP3A5 rs776746 in tacrolimus concentration variability. They also identified several novel SNPs, with a reasonably strong association, which have the potential to become useful predictors of post-transplant complications. However, as the studies were typically conducted in one center on relatively low-to-moderate number of patients, verification of the results in other centers is warranted to resolve these limitations. Furthermore, of 29 reviewed studies, 28 used gene candidate approach and only one implemented a genome wide association approach. Genome wide association multicentric studies are needed to facilitate the development of personalized transplant medicine.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-UIP-2017-05-1965 - Uloga Notch signalnog puta u patogenezi jetrene fibroze (NOFIBRO) (Kelava, Tomislav, HRZZ - 2017-05) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinička bolnica "Merkur",
Medicinski fakultet, Zagreb

Profili:

Avatar Url Petra Turčić (autor)

Avatar Url Anna Mrzljak (autor)

Avatar Url Dino Šisl (autor)

Avatar Url Ana Ostojić (autor)

Avatar Url Tomislav Kelava (autor)

doi

Citiraj ovu publikaciju

Kelava, Tomislav; Turcic, Petra; Markotic, Antonio; Ostojic, Ana; Sisl, Dino; Mrzljak, Anna
Importance of genetic polymorphisms in liver transplantation outcomes // World Journal of Gastroenterology, 26 (2020), 12; 1273-1285 doi:10.3748/wjg.v26.i12.1273 (međunarodna recenzija, pregledni rad, ostalo)
Kelava, T., Turcic, P., Markotic, A., Ostojic, A., Sisl, D. & Mrzljak, A. (2020) Importance of genetic polymorphisms in liver transplantation outcomes. World Journal of Gastroenterology, 26 (12), 1273-1285 doi:10.3748/wjg.v26.i12.1273.
@article{article, year = {2020}, pages = {1273-1285}, DOI = {10.3748/wjg.v26.i12.1273}, keywords = {Acute rejection, Hepatocellular carcinoma, Liver transplantation, New-onset diabetes mellitus, Non-alcoholic fatty liver disease, Single nucleotide polymorphisms, Tacrolimus.}, journal = {World Journal of Gastroenterology}, doi = {10.3748/wjg.v26.i12.1273}, volume = {26}, number = {12}, issn = {1007-9327}, title = {Importance of genetic polymorphisms in liver transplantation outcomes}, keyword = {Acute rejection, Hepatocellular carcinoma, Liver transplantation, New-onset diabetes mellitus, Non-alcoholic fatty liver disease, Single nucleotide polymorphisms, Tacrolimus.} }
@article{article, year = {2020}, pages = {1273-1285}, DOI = {10.3748/wjg.v26.i12.1273}, keywords = {Acute rejection, Hepatocellular carcinoma, Liver transplantation, New-onset diabetes mellitus, Non-alcoholic fatty liver disease, Single nucleotide polymorphisms, Tacrolimus.}, journal = {World Journal of Gastroenterology}, doi = {10.3748/wjg.v26.i12.1273}, volume = {26}, number = {12}, issn = {1007-9327}, title = {Importance of genetic polymorphisms in liver transplantation outcomes}, keyword = {Acute rejection, Hepatocellular carcinoma, Liver transplantation, New-onset diabetes mellitus, Non-alcoholic fatty liver disease, Single nucleotide polymorphisms, Tacrolimus.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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