engleski

Severe immune hemolytic anemia associated with warm-reacting IgM autoantibodies: a diagnostic (and therapeutic) challenge

Autoimmune hemolytic anemia (AIHA) can present with severe intraand extravascular hemolysis. In warm AIHA (WAIHA), characterised by IgG autoantibodies, hemolysis is tipically extravascular ; however, complement-mediated intravascular hemolysis can be seen in “mixed” type AIHA, characterised by both IgG warm autoantibodies and IgM cold autoantibodies reactive up to 30 to 37°C, and in rare WAIHA caused by IgM warm autoantibodies. Diagnostic of IgM WAIHA is very difficult. It can be confused with cold agglutinin syndrome, caused by IgM cold autoantibodies reactive up to 30°C or with “mixed” type AIHA. Although death from WAIHA is considered rare (4–11%), it is particularly high (22%) in IgM WAIHA.

Immune hemolytic anemia, warm-reacting IgM autoantibodies

nije evidentirano