engleski

Managing patients with antibodies to high- frequency antigens - our experience

An investigation of the antibody to a high- frequency antigen (HFA) is both very demanding and time consuming. Although some of the antibodies that are serologically difficult to identify are those with the least clinical significance (i.e. anti-Csa, -Ch, -Rg, -Yta, -JMH), many have been responsible for immediate HTR (i.g. anti-Vel, Inb), delayed HTR (i.g. anti-Kpb, - Jsb), severe HDFN (i.g. anti-k, anti-RH17) or mild HDFN (i.g. anti-K18) where antigen negative blood should be transfused. While HFA-negative subjects are excessively rare amongst white people, transfusion management in patients with HFA alloantibodies is often difficult.

Antibodies to high-frequency antigens

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