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Pregled bibliografske jedinice broj: 1073280

Thienochromene derivatives inhibit pSTAT1 and pSTAT5 signaling induced by cytokines


Wittine, Karlo; Antolović, Roberto; Jelić, Dubravko; Bracanović, Sara; Cetina, Mario; Andjelkovic, Uroš; Wittine, Ozren; Kraljević Pavelić, Sandra; Vinter, Adrijana
Thienochromene derivatives inhibit pSTAT1 and pSTAT5 signaling induced by cytokines // Bioorganic & medicinal chemistry letters, 30 (2020), 18; 127415, 5 doi:10.1016/j.bmcl.2020.127415 (međunarodna recenzija, članak, znanstveni)


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Naslov
Thienochromene derivatives inhibit pSTAT1 and pSTAT5 signaling induced by cytokines

Autori
Wittine, Karlo ; Antolović, Roberto ; Jelić, Dubravko ; Bracanović, Sara ; Cetina, Mario ; Andjelkovic, Uroš ; Wittine, Ozren ; Kraljević Pavelić, Sandra ; Vinter, Adrijana

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 30 (2020), 18; 127415, 5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Thieno[3, 2-c]chromene ; Coumarin ; Anti-inflammatory ; Interleukin ; Cytokine ; JAK/STAT

Sažetak
Furanocoumarins, particularly furo[3, 2- c]coumarins, are found in many natural products. However, coumarins annulated to a thiophene ring have received scarce attention to date in the literature. Therefore, we synthesized 4-oxo-4H-thieno[3, 2-c]chromene derivatives and tested in vitro their anti- inflammatory activity. Anti-inflammatory potential of the synthesized compounds (1, 2, 6–8, 9a–e and 10a–c) has been evaluated by measuring various pSTAT (signal transducer and activator of transcription) inhibition within the JAK (Janus-activated family kinase)/STAT signaling pathway. Ethyl 7-hydroxy-4-oxo-4H- thieno[3, 2-c]chromene-2-carboxylate (7) showed best inhibition properties on pSTAT5 in GM-CSF (Granulocyte-macrophage colony-stimulating factor)-triggered PBMC assay, with IC50 value of 5.0 µM.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Ustanove:
Tekstilno-tehnološki fakultet, Zagreb,
PLIVA HRVATSKA d.o.o.,
Fidelta d.o.o.,
Sveučilište u Rijeci - Odjel za biotehnologiju

Citiraj ovu publikaciju

Wittine, Karlo; Antolović, Roberto; Jelić, Dubravko; Bracanović, Sara; Cetina, Mario; Andjelkovic, Uroš; Wittine, Ozren; Kraljević Pavelić, Sandra; Vinter, Adrijana
Thienochromene derivatives inhibit pSTAT1 and pSTAT5 signaling induced by cytokines // Bioorganic & medicinal chemistry letters, 30 (2020), 18; 127415, 5 doi:10.1016/j.bmcl.2020.127415 (međunarodna recenzija, članak, znanstveni)
Wittine, K., Antolović, R., Jelić, D., Bracanović, S., Cetina, M., Andjelkovic, U., Wittine, O., Kraljević Pavelić, S. & Vinter, A. (2020) Thienochromene derivatives inhibit pSTAT1 and pSTAT5 signaling induced by cytokines. Bioorganic & medicinal chemistry letters, 30 (18), 127415, 5 doi:10.1016/j.bmcl.2020.127415.
@article{article, year = {2020}, pages = {5}, DOI = {10.1016/j.bmcl.2020.127415}, chapter = {127415}, keywords = {Thieno[3, 2-c]chromene, Coumarin, Anti-inflammatory, Interleukin, Cytokine, JAK/STAT}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2020.127415}, volume = {30}, number = {18}, issn = {0960-894X}, title = {Thienochromene derivatives inhibit pSTAT1 and pSTAT5 signaling induced by cytokines}, keyword = {Thieno[3, 2-c]chromene, Coumarin, Anti-inflammatory, Interleukin, Cytokine, JAK/STAT}, chapternumber = {127415} }
@article{article, year = {2020}, pages = {5}, DOI = {10.1016/j.bmcl.2020.127415}, chapter = {127415}, keywords = {Thieno[3, 2-c]chromene, Coumarin, Anti-inflammatory, Interleukin, Cytokine, JAK/STAT}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2020.127415}, volume = {30}, number = {18}, issn = {0960-894X}, title = {Thienochromene derivatives inhibit pSTAT1 and pSTAT5 signaling induced by cytokines}, keyword = {Thieno[3, 2-c]chromene, Coumarin, Anti-inflammatory, Interleukin, Cytokine, JAK/STAT}, chapternumber = {127415} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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