engleski

Effects of Sertaline Treatment on Plasma Cortisol, Prolactin and Thyroid Hormones in Female Depressed Patients

The aim of the study was to evaluate the effects of 4 and 24 weeks of sertaline treatment (average dose 42, 5 mg/day) on plasma hormone levels in 15 female patients with major depression.There was a positive correlation between the scores on the Montgomery-Asperg- Depression Rating Scale and baseline cortisol levels.Treatmnent with sertaline for 4 weeks increased plasma cortisol levels, while 24 weeks of sertraline treatment increased plasma T3 levels in depressed patients. Neither 4, nor 24 weeks of sertraline treatment affected PRL, T4 and TSH levels in depressed patients. The data show different and time-dependent effects of sertraline treatment on plasma cortisol, PRL and thyroid hormones in female depressed patients.

sertaline; major depression; cortisol; prolactin; triiodothyronine; thyroxine; TSH

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