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Pregled bibliografske jedinice broj: 1073086

Inhibitori histonskih deacetilaza kao protutumorski lijekovi


Poje, Goran; Rajić, Zrinka
Inhibitori histonskih deacetilaza kao protutumorski lijekovi // Farmaceutski glasnik : glasilo Hrvatskog farmaceutskog društva, 76 (2020), 261-280 (domaća recenzija, pregledni rad, stručni)


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Naslov
Inhibitori histonskih deacetilaza kao protutumorski lijekovi
(Histone deacetylase inhibitors as antitumour drugs)

Autori
Poje, Goran ; Rajić, Zrinka

Izvornik
Farmaceutski glasnik : glasilo Hrvatskog farmaceutskog društva (0014-8202) 76 (2020); 261-280

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
histonska deacetilaza, citostatik, inhibitor
(hzstone deacetylase, cytostatic, inhibitor)

Sažetak
Histone deacetylases (HDACs) catalyze the removal of the acetyl group from an ε-N-acetyl lysine on a histone, resulting in a more tight DNA structure. In this way, they affect chromatin structure and gene expression. They catalyze the same reaction on some non-histone proteins. Inhibition of overexpressed HDACs in tumour cells results in cell cycle arrest, induction of apoptosis, inhibition of angiogenesis and regulation of cellular signaling pathways in a survival-negative manner. Out of 4 known HDAC classes, classes I, II and IV are zinc-dependent enzymes, while class III is NAD+ dependent. All known HDACs inhibitors contain zinc-binding group, responsible for complexation of Zn2+ from the enzyme's active site. Other main structural features include cap group and the linker. With respect to the zinc-binding group, inhibitors can be divided into hydroxamic acids (the most pronounced ability to chelate Zn2+), carboxylic acids, cyclic peptides, and o-aminoanilides. Up to date, five HDACs inhibitors have reached the market: vorinostat, belinostat, and panobinostat (hydroxamic acids), romidepsin (cyclic peptide) and chidamide (o- aminoanilide). They are used in the therapy of T- cell lymphomas and multiple myeloma.

Izvorni jezik
Hrvatski

Znanstvena područja
Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Goran Poje (autor)

Citiraj ovu publikaciju

Poje, Goran; Rajić, Zrinka
Inhibitori histonskih deacetilaza kao protutumorski lijekovi // Farmaceutski glasnik : glasilo Hrvatskog farmaceutskog društva, 76 (2020), 261-280 (domaća recenzija, pregledni rad, stručni)
Poje, G. & Rajić, Z. (2020) Inhibitori histonskih deacetilaza kao protutumorski lijekovi. Farmaceutski glasnik : glasilo Hrvatskog farmaceutskog društva, 76, 261-280.
@article{article, year = {2020}, pages = {261-280}, keywords = {hzstone deacetylase, cytostatic, inhibitor}, journal = {Farmaceutski glasnik : glasilo Hrvatskog farmaceutskog dru\v{s}tva}, volume = {76}, issn = {0014-8202}, title = {Histone deacetylase inhibitors as antitumour drugs}, keyword = {hzstone deacetylase, cytostatic, inhibitor} }

Časopis indeksira:


  • Scopus





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