Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1072147

Effect of differently coated silver nanoparticles on hemostasis


(COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside”) Milić, Marija; Vuković, Barbara; Barbir, Rinea; Pem, Barbara; Milić, Mirta; Šerić, Vatroslav; Frőhlich, Eleonore; Vinković Vrček, Ivana
Effect of differently coated silver nanoparticles on hemostasis // Platelets (2020) doi:10.1080/09537104.2020.1792432 (znanstveni, prihvaćen)


CROSBI ID: 1072147 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effect of differently coated silver nanoparticles on hemostasis

Autori
Milić, Marija ; Vuković, Barbara ; Barbir, Rinea ; Pem, Barbara ; Milić, Mirta ; Šerić, Vatroslav ; Frőhlich, Eleonore ; Vinković Vrček, Ivana

Kolaboracija
COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside”

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Platelets (2020)

Status rada
Prihvaćen

Ključne riječi
Blood coagulation, hemolysis, nano-enabled medical devices, platelet aggregation

Sažetak
With the emergence of nano-enabled medical devices (MDs) for the use in human medicine, ensuring their safety becomes of crucial importance. Hemocompatibility is one of the major criteria for approval of all MDs in contact with blood (e.g. vascular grafts, stents, or valves). Silver nanoparticles (AgNPs) are among the most used nanomaterials for MDs due to their biocidal activity ; however, detailed knowledge on their hemostatic effects is still lacking. This study aimed to evaluate comprehensively AgNPs effects on hemostasis in human blood by exploiting combination of affordable and clinically relevant techniques. Differently stabilized AgNPs were prepared using sodium bis(2-ethylhexyl)sulphosuccinate (AOT), polyvinylpyrrolidone (PVP), poly-L-lysine (PLL), and bovine serum albumin (BSA) as coating agents. They were tested for hemolytic activity, induction of platelet aggregation, plasmatic coagulation, thrombin generation, and hemostasis in whole blood. All AgNPs were found to cause dose-dependent hemolysis. The BSA-, AOT-, and PVP-coated AgNPs delayed plasmatic coagulation, while only PLL-AgNPs inhibited plasmatic coagulation, induced platelet activation, and interfered with hemostasis by delaying clotting time and decreasing clot firmness in whole blood. Obtained results demonstrate that a combination of different techniques should be used for reliable assessment of AgNPs hemostatic effects highlighting the need for a standardized approach in sampling and experimental protocols.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2016-06-2436 - Značaj interakcija metalnih nanočestica sa sumpornim biomolekulama za nano-bio sučelje (Ivana Vinković Vrček, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek

Citiraj ovu publikaciju

(COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside”) Milić, Marija; Vuković, Barbara; Barbir, Rinea; Pem, Barbara; Milić, Mirta; Šerić, Vatroslav; Frőhlich, Eleonore; Vinković Vrček, Ivana
Effect of differently coated silver nanoparticles on hemostasis // Platelets (2020) doi:10.1080/09537104.2020.1792432 (znanstveni, prihvaćen)
(COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside”) (COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside”) Milić, M., Vuković, B., Barbir, R., Pem, B., Milić, M., Šerić, V., Frőhlich, E. & Vinković Vrček, I. (2020) Effect of differently coated silver nanoparticles on hemostasis. Prihvaćen za objavljivanje u Platelets. [Preprint] doi:10.1080/09537104.2020.1792432.
@unknown{unknown, year = {2020}, DOI = {10.1080/09537104.2020.1792432}, keywords = {Blood coagulation, hemolysis, nano-enabled medical devices, platelet aggregation}, journal = {Platelets}, doi = {10.1080/09537104.2020.1792432}, title = {Effect of differently coated silver nanoparticles on hemostasis}, keyword = {Blood coagulation, hemolysis, nano-enabled medical devices, platelet aggregation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati