Celiac Disease in Kosovar Albanian Children: Evaluation of Clinical Features and Diagnosis (CROSBI ID 281066)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Ramosaj-Morina, Atifete ; Keka-Sylaj, Alije ; Zejnullahu, Arbana Baloku ; Spahiu, Lidvana ; Hasbahta, Virgjina ; Jaha, Vlora ; Kotori, Vjosa ; Bicaj, Besnik ; Kurshumliu, Fisnik ; Zhjeqi, Valbona ; Kamenaric-Burek, Marija ; Zunec, Renata
engleski
Celiac Disease in Kosovar Albanian Children: Evaluation of Clinical Features and Diagnosis
Background: Celiac disease is an immune-mediated disorder characterized by a variable clinical manifestations, specific antibodies, HLA-DQ2/DQ8 haplotypes, and enteropathy. Objectives: Aim of this study was to present clinical spectrum and patterns of celiac disease in Kosovar Albanian children. Methods: A cross-sectional retrospective study was performed with Albanian children aged 0-18 years, treated for celiac disease in the Pediatric Clinic, University Clinical Center of Kosovo from 2005 to 2016. Results: During the study period, 63 children were treated for celiac disease. The mean age at diagnosis was 5.5 years (SD ± 3.31). The mean age at celiac disease onset was 3.3 years (SD ± 2.02), while the mean delay from the first symptoms indicative of celiac disease to diagnosis was 2.2 years (SD ± 2.09). More than 70% of the patients were diagnosed in the first 7 years of life, mainly presented with gastrointestinal symptoms, while primary school children and adolescents mostly showed atypical symptoms (p<0.001). The classical form of celiac disease occurred in 78% of the cases. Sixty (95%) patients carried HLA-DQ2.5, DQ2.2 and/or HLA-DQ8 heterodimers, and only three of them tested negative. Conclusions: Kosovo as the majority of developing countries, is still facing with the classical form of celiac disease as the dominant mode of presentation ; as a result, most children with other forms of celiac disease remain undiagnosed. Physicians should be aware of the wide range of clinical presentation and utilize low testing threshold in order to prevent potential long-term problems associated with untreated celiac disease.
Children ; Classical coeliac disease ; Developing countries ; Screening ; Symptoms
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Podaci o izdanju
16
2020.
31951185
5
objavljeno
1573-3963
1875-6336
10.2174/1573396316666200116093753
Povezanost rada
Biologija, Kliničke medicinske znanosti