Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1071359

The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease


Culjak, Marija; Nikolac Perković, Matea; Uzun, Suzana; Švob Štrac, Dubravka; Nedić Erjavec, Gordana; Babić Leko, Mirjana; Šimić, Goran; Tudor, Lucija; Konjevod, Marcela; Kozumplik, Oliver et al.
The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease // Current Alzheimer research (2020) (znanstveni, prihvaćen)


CROSBI ID: 1071359 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease

Autori
Culjak, Marija ; Nikolac Perković, Matea ; Uzun, Suzana ; Švob Štrac, Dubravka ; Nedić Erjavec, Gordana ; Babić Leko, Mirjana ; Šimić, Goran ; Tudor, Lucija ; Konjevod, Marcela ; Kozumplik, Oliver ; Mimica, Ninoslav ; Pivac, Nela

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Current Alzheimer research (2020)

Status rada
Prihvaćen

Ključne riječi
Alzheimer's disease ; mild cognitive impairment ; TNF-alfa rs1800629 ; IL-1-alfa rs1800587 ; IL-10 rs1800896 ; IL-1alfa ; IL-10 ; TNF-alfa

Sažetak
BACKGROUND: Sporadic Alzheimer's Disease (AD) is assumed to be associated with different biological/genetic vulnerability, as well as with neuroinflammation, mediated by cytokines. The present study evaluated the role of cytokines in AD. OBJECTIVE: Aim was to determine the possible association of TNF-alpha (rs1800629), IL1- alpha (rs1800587) and IL-10 (rs1800896) polymorphisms with AD, and to assess serum TNF-alpha, IL-1alpha and IL-10 concentrations in patients with AD and in subjects with mild cognitive impairment (MCI). METHOD: The study included 645 Caucasian participants: 395 subjects with AD and 250 subjects with MCI. Genotyping was performed using real time PCR in all 645 subjects, while serum concentrations of TNF-a, IL-1alpha and 1L-10 and were determined using ELISA in 174 subjects. RESULTS: The frequency of the TNF- alpha rs1800629, IL 1-alpha rs1800587 or IL-10 rs1800896 genotypes did not differ significantly between patients with AD and MCI. Serum concentration of IL-1alpha and IL-10 were significantly decreased, while the concentration of TNF-alpha was significantly higher in patients with AD than in MCI subjects. TNF-alpha, IL1-alpha or IL-10 concentrations were similar in subjects with AD or MCI subdivided into carriers of the corresponding TNF-alpha rs1800629, IL1-alpha rs1800587 or IL-10 rs1800896 genotypes. CONCLUSIONS: Similar distribution of the IL1-alpha rs1800587, TNF-alpha rs1800629 or IL-10 rs1800896 genotypes in subjects with AD and MCI failed to confirm that these specific risk genotypes are associated with vulnerability to develop AD. Alteration in IL-1alpha, IL-10 and TNF- alpha concentrations in patients with AD partially confirmed the association with neuroinflammatory response in AD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Medicinski fakultet, Osijek,
Sveučilište u Zagrebu,
Sveučilište J. J. Strossmayera u Osijeku

Citiraj ovu publikaciju

Culjak, Marija; Nikolac Perković, Matea; Uzun, Suzana; Švob Štrac, Dubravka; Nedić Erjavec, Gordana; Babić Leko, Mirjana; Šimić, Goran; Tudor, Lucija; Konjevod, Marcela; Kozumplik, Oliver et al.
The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease // Current Alzheimer research (2020) (znanstveni, prihvaćen)
Culjak, M., Nikolac Perković, M., Uzun, S., Švob Štrac, D., Nedić Erjavec, G., Babić Leko, M., Šimić, G., Tudor, L., Konjevod, M. & Kozumplik, O. (2020) The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease. Prihvaćen za objavljivanje u Current Alzheimer research. [Preprint].
@unknown{unknown, year = {2020}, keywords = {Alzheimer's disease, mild cognitive impairment, TNF-alfa rs1800629, IL-1-alfa rs1800587, IL-10 rs1800896, IL-1alfa, IL-10, TNF-alfa}, journal = {Current Alzheimer research}, title = {The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease}, keyword = {Alzheimer's disease, mild cognitive impairment, TNF-alfa rs1800629, IL-1-alfa rs1800587, IL-10 rs1800896, IL-1alfa, IL-10, TNF-alfa} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE