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Pregled bibliografske jedinice broj: 1071359

The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease


Culjak, Marija; Nikolac Perković, Matea; Uzun, Suzana; Švob Štrac, Dubravka; Nedić Erjavec, Gordana; Babić Leko, Mirjana; Šimić, Goran; Tudor, Lucija; Konjevod, Marcela; Kozumplik, Oliver et al.
The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease // Current Alzheimer research, 17 (2020), 11; 972-984 doi:10.2174/1567205017666201130092427 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1071359 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease
(The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease)

Autori
Culjak, Marija ; Nikolac Perković, Matea ; Uzun, Suzana ; Švob Štrac, Dubravka ; Nedić Erjavec, Gordana ; Babić Leko, Mirjana ; Šimić, Goran ; Tudor, Lucija ; Konjevod, Marcela ; Kozumplik, Oliver ; Mimica, Ninoslav ; Pivac, Nela

Izvornik
Current Alzheimer research (1567-2050) 17 (2020), 11; 972-984

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alzheimer's disease ; mild cognitive impairment ; TNF-alfa rs1800629 ; IL-1-alfa rs1800587 ; IL-10 rs1800896 ; IL-1alfa ; IL-10 ; TNF-alfa

Sažetak
BACKGROUND: Sporadic Alzheimer's Disease (AD) is assumed to be associated with different biological/genetic vulnerability, as well as with neuroinflammation, mediated by cytokines. The present study evaluated the role of cytokines in AD. OBJECTIVE: Aim was to determine the possible association of TNF-alpha (rs1800629), IL1- alpha (rs1800587) and IL-10 (rs1800896) polymorphisms with AD, and to assess serum TNF-alpha, IL-1alpha and IL-10 concentrations in patients with AD and in subjects with mild cognitive impairment (MCI). METHOD: The study included 645 Caucasian participants: 395 subjects with AD and 250 subjects with MCI. Genotyping was performed using real time PCR in all 645 subjects, while serum concentrations of TNF-a, IL-1alpha and 1L-10 and were determined using ELISA in 174 subjects. RESULTS: The frequency of the TNF- alpha rs1800629, IL 1-alpha rs1800587 or IL-10 rs1800896 genotypes did not differ significantly between patients with AD and MCI. Serum concentration of IL-1alpha and IL-10 were significantly decreased, while the concentration of TNF-alpha was significantly higher in patients with AD than in MCI subjects. TNF-alpha, IL1- alpha or IL-10 concentrations were similar in subjects with AD or MCI subdivided into carriers of the corresponding TNF-alpha rs1800629, IL1-alpha rs1800587 or IL-10 rs1800896 genotypes. CONCLUSIONS: Similar distribution of the IL1-alpha rs1800587, TNF- alpha rs1800629 or IL-10 rs1800896 genotypes in subjects with AD and MCI failed to confirm that these specific risk genotypes are associated with vulnerability to develop AD. Alteration in IL-1alpha, IL-10 and TNF- alpha concentrations in patients with AD partially confirmed the association with neuroinflammatory response in AD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Sveučilište u Zagrebu

Citiraj ovu publikaciju

Culjak, Marija; Nikolac Perković, Matea; Uzun, Suzana; Švob Štrac, Dubravka; Nedić Erjavec, Gordana; Babić Leko, Mirjana; Šimić, Goran; Tudor, Lucija; Konjevod, Marcela; Kozumplik, Oliver et al.
The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease // Current Alzheimer research, 17 (2020), 11; 972-984 doi:10.2174/1567205017666201130092427 (međunarodna recenzija, članak, znanstveni)
Culjak, M., Nikolac Perković, M., Uzun, S., Švob Štrac, D., Nedić Erjavec, G., Babić Leko, M., Šimić, G., Tudor, L., Konjevod, M. & Kozumplik, O. (2020) The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease. Current Alzheimer research, 17 (11), 972-984 doi:10.2174/1567205017666201130092427.
@article{article, year = {2020}, pages = {972-984}, DOI = {10.2174/1567205017666201130092427}, keywords = {Alzheimer's disease, mild cognitive impairment, TNF-alfa rs1800629, IL-1-alfa rs1800587, IL-10 rs1800896, IL-1alfa, IL-10, TNF-alfa}, journal = {Current Alzheimer research}, doi = {10.2174/1567205017666201130092427}, volume = {17}, number = {11}, issn = {1567-2050}, title = {The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease}, keyword = {Alzheimer's disease, mild cognitive impairment, TNF-alfa rs1800629, IL-1-alfa rs1800587, IL-10 rs1800896, IL-1alfa, IL-10, TNF-alfa} }
@article{article, year = {2020}, pages = {972-984}, DOI = {10.2174/1567205017666201130092427}, keywords = {Alzheimer's disease, mild cognitive impairment, TNF-alfa rs1800629, IL-1-alfa rs1800587, IL-10 rs1800896, IL-1alfa, IL-10, TNF-alfa}, journal = {Current Alzheimer research}, doi = {10.2174/1567205017666201130092427}, volume = {17}, number = {11}, issn = {1567-2050}, title = {The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's disease}, keyword = {Alzheimer's disease, mild cognitive impairment, TNF-alfa rs1800629, IL-1-alfa rs1800587, IL-10 rs1800896, IL-1alfa, IL-10, TNF-alfa} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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