Parameter identification in the mathematical model of glucose and insulin tolerance test – the mathematical markers of diabetes (CROSBI ID 280895)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Heffer, Marija ; Ivić, Vedrana ; Scitovski, Rudolf
engleski
Parameter identification in the mathematical model of glucose and insulin tolerance test – the mathematical markers of diabetes
Glucose tolerance test (GTT) is standard diagnostic procedure that tests the efficiency of blood glucose-lowering hormones (insulin, incretins, leptin). Contrary, insulin tolerance test (ITT) is probing efficiency of blood glucose-rising hormones (glucagon, thyroxine, growth hormone, glucocorticoids, adrenalin, noradrenalin). These two hormone systems together maintain blood glucose levels in a narrow range. Various pathophysiological mechanisms give rise to a reversible condition - prediabetes which then progresses to an irreversible chronic disease - diabetes, both marked with deviation of blood glucose levels outside the set range. In diagnostic purpose, the patient is given glucose load, and blood glucose is measured right before and 2 hours after load. Measurements are more frequent after insulin injection (ITT) or if both tests are performed on experimental animals. In this paper we analyse the mathematical model for GTT and ITT. The obtained model function is an useful tool in describing the dynamics of blood glucose changes.
glucose tolerance test ; insulin tolerance test ; mathematical model ; parameter identification
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Podaci o izdanju
11 (1)
2020.
121-133
objavljeno
1848-0225
1848-9931
10.17535/crorr.2020.0010
Povezanost rada
Matematika, Temeljne medicinske znanosti