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Pregled bibliografske jedinice broj: 1070901

Association of HSPA1B genotypes with psychopathology and neurocognition in patients with the first episode of psychosis: a longitudinal 18-month follow-up study


Bosnjak Kuharic, Dina; Bozina, Nada; Ganoci, Lana; Makaric, Porin; Kekin, Ivana; Prpic, Nikola; Bozina, Tamara; Rojnic Kuzman, Martina
Association of HSPA1B genotypes with psychopathology and neurocognition in patients with the first episode of psychosis: a longitudinal 18-month follow-up study // Pharmacogenomics journal, Feb 4 (2020), 32015459, 9 doi:10.1038/s41397-020-0150-9 (međunarodna recenzija, članak, znanstveni)


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Naslov
Association of HSPA1B genotypes with psychopathology and neurocognition in patients with the first episode of psychosis: a longitudinal 18-month follow-up study

Autori
Bosnjak Kuharic, Dina ; Bozina, Nada ; Ganoci, Lana ; Makaric, Porin ; Kekin, Ivana ; Prpic, Nikola ; Bozina, Tamara ; Rojnic Kuzman, Martina

Izvornik
Pharmacogenomics journal (1470-269X) Feb 4 (2020); 32015459, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
schizophrenia and psychosis ; HSPA1B ; genetics ; psychopharmacogenetics

Sažetak
Our aim was to analyze the association of HSPA1B genotypes and treatment response measured by the changes of psychopathology and neurocognitive symptoms in patients with first- episode psychosis (FEP) after 18 months of treatment. A sample of 159 patients with FEP admitted at two Croatian psychiatric hospitals in the period between year 2014 and year 2017 was assessed at baseline and after 18 months of follow-up with Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS) and a battery of neurocognitive tests. Associations of scale and test results with HSPA1B polymorphic locus rs1061581 were analyzed using the general linear model. The carriers of the AA genotype showed the highest improvement in CDSS and RAVLT A test after the 18-month follow-up. Concordantly, we found significantly higher improvement assessed with the CDSS, RAVLT A, RAVLT A 30′ and positive PANSS scales in the not-GG (AA/AG) group compared with the GG group. Our study suggests that HSPA1B rs1061581variants may moderate treatment response in FEP measured with changes of psychopathology and neurocognitive test results.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-UIP-2014-09-1245 - Biomarkeri u shizofreniji – integracija komplementarnih prisutupa u praćenju osoba s prvom psihotičnom epizodom (Martina Rojnic Kuzman, )

Ustanove
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Lana Ganoci (autor)

Avatar Url Nada Božina (autor)

Avatar Url Martina Rojnić Kuzman (autor)

Avatar Url Tamara Božina (autor)

Citiraj ovu publikaciju

Bosnjak Kuharic, Dina; Bozina, Nada; Ganoci, Lana; Makaric, Porin; Kekin, Ivana; Prpic, Nikola; Bozina, Tamara; Rojnic Kuzman, Martina
Association of HSPA1B genotypes with psychopathology and neurocognition in patients with the first episode of psychosis: a longitudinal 18-month follow-up study // Pharmacogenomics journal, Feb 4 (2020), 32015459, 9 doi:10.1038/s41397-020-0150-9 (međunarodna recenzija, članak, znanstveni)
Bosnjak Kuharic, D., Bozina, N., Ganoci, L., Makaric, P., Kekin, I., Prpic, N., Bozina, T. & Rojnic Kuzman, M. (2020) Association of HSPA1B genotypes with psychopathology and neurocognition in patients with the first episode of psychosis: a longitudinal 18-month follow-up study. Pharmacogenomics journal, Feb 4, 32015459, 9 doi:10.1038/s41397-020-0150-9.
@article{article, year = {2020}, pages = {9}, DOI = {10.1038/s41397-020-0150-9}, chapter = {32015459}, keywords = {schizophrenia and psychosis, HSPA1B, genetics, psychopharmacogenetics}, journal = {Pharmacogenomics journal}, doi = {10.1038/s41397-020-0150-9}, volume = {Feb 4}, issn = {1470-269X}, title = {Association of HSPA1B genotypes with psychopathology and neurocognition in patients with the first episode of psychosis: a longitudinal 18-month follow-up study}, keyword = {schizophrenia and psychosis, HSPA1B, genetics, psychopharmacogenetics}, chapternumber = {32015459} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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