Pregled bibliografske jedinice broj: 1070477
Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori
Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori // FEBS Practical/Lecture Course 2018 - Ligand-binding theory and practice
Nové Hrady, Češka Republika, 2018. (poster, nije recenziran, neobjavljeni rad, znanstveni)
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Naslov
Catalytic Properties of Adenylosuccinate Synthetase from
Pathogen Helicobacter pylori
Autori
Bubić, Ante ; Leščić Ašler, Ivana ; Luić, Marija
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni
Skup
FEBS Practical/Lecture Course 2018 - Ligand-binding theory and practice
Mjesto i datum
Nové Hrady, Češka Republika, 24.06.2018. - 01.07.2018
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
Ligand, Binding, Protein, FEBS
Sažetak
Elicobacter pylori is a Gram-negative microaerophilic bacterium that chronically colonizes the gastric epithelium. This bacterium plays a significant role in the development of several gastrointestinal diseases ; including non-symptomatic chronic gastritis, peptic ulcer disease, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. Adenylosuccinate synthetase is one of the essential enzymes in purine salvage pathway which catalyzes condensation of IMP with L-aspartate to form adenylosuccinate by hydrolyzing GTP in the presence of Mg 2+ ions. Bioinformatic studies showed that H. pylori lacks the genes for de novo synthesis of purines. Consequently, the viability of H. pylori relies on salvage pathway for purine synthesis. Therefore, AdSS is a potential drug target.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija
