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Pregled bibliografske jedinice broj: 1070477

Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori


Bubić, Ante; Leščić Ašler, Ivana; Luić, Marija
Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori // FEBS Practical/Lecture Course 2018 - Ligand-binding theory and practice
Nove Hrady, Češka, 2018. (poster, nije recenziran, neobjavljeni rad, znanstveni)


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Naslov
Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori

Autori
Bubić, Ante ; Leščić Ašler, Ivana ; Luić, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
FEBS Practical/Lecture Course 2018 - Ligand-binding theory and practice

Mjesto i datum
Nove Hrady, Češka, 24.6.-1.7.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Ligand, Binding, Protein, FEBS

Sažetak
Elicobacter pylori is a Gram-negative microaerophilic bacterium that chronically colonizes the gastric epithelium. This bacterium plays a significant role in the development of several gastrointestinal diseases ; including non-symptomatic chronic gastritis, peptic ulcer disease, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. Adenylosuccinate synthetase is one of the essential enzymes in purine salvage pathway which catalyzes condensation of IMP with L-aspartate to form adenylosuccinate by hydrolyzing GTP in the presence of Mg 2+ ions. Bioinformatic studies showed that H. pylori lacks the genes for de novo synthesis of purines. Consequently, the viability of H. pylori relies on salvage pathway for purine synthesis. Therefore, AdSS is a potential drug target.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Profili:

Avatar Url Ivana Leščić Ašler (autor)

Avatar Url Marija Luić (autor)

Avatar Url Ante Bubić (autor)


Citiraj ovu publikaciju:

Bubić, Ante; Leščić Ašler, Ivana; Luić, Marija
Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori // FEBS Practical/Lecture Course 2018 - Ligand-binding theory and practice
Nove Hrady, Češka, 2018. (poster, nije recenziran, neobjavljeni rad, znanstveni)
Bubić, A., Leščić Ašler, I. & Luić, M. (2018) Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori. U: FEBS Practical/Lecture Course 2018 - Ligand-binding theory and practice.
@article{article, year = {2018}, keywords = {Ligand, Binding, Protein, FEBS}, title = {Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori}, keyword = {Ligand, Binding, Protein, FEBS}, publisherplace = {Nove Hrady, \v{C}e\v{s}ka} }
@article{article, year = {2018}, keywords = {Ligand, Binding, Protein, FEBS}, title = {Catalytic Properties of Adenylosuccinate Synthetase from Pathogen Helicobacter pylori}, keyword = {Ligand, Binding, Protein, FEBS}, publisherplace = {Nove Hrady, \v{C}e\v{s}ka} }




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