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Pregled bibliografske jedinice broj: 1069183

Photolytic and photocatalytic degradation of doxazosin in aqueous solution


Tartaro Bujak, Ivana; Bavcon Kralj, Mojca; Kosyakov, Dmitry S.; Ul'yanovskii, Nikolay V.; Lebedev, Albert T.; Trebše, Polonca
Photolytic and photocatalytic degradation of doxazosin in aqueous solution // Science of the total environment, 740 (2020), 140131, 8 doi:10.1016/j.scitotenv.2020.140131 (međunarodna recenzija, članak, znanstveni)


Naslov
Photolytic and photocatalytic degradation of doxazosin in aqueous solution

Autori
Tartaro Bujak, Ivana ; Bavcon Kralj, Mojca ; Kosyakov, Dmitry S. ; Ul'yanovskii, Nikolay V. ; Lebedev, Albert T. ; Trebše, Polonca

Izvornik
Science of the total environment (0048-9697) 740 (2020); 140131, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Doxazosin ; Photolysis ; Photocatalysis ; LC-MS ; Toxicity

Sažetak
Doxazosin (DOX), a selective alpha blocker, is widely used in medical therapy as an effective antihypertensive agent. It is a frequently prescribed drug and for this reason, environmental and ecotoxicological research is of great importance in terms of exposure and risk for both aquatic species and humans. In this study we focused on photolytic and TiO2 photocatalytic degradation processes of doxazosin under different simulated conditions, with the emphasis on identification of degradation products. Photolytic (without TiO2) experiments were performed in the presence and absence of oxygen, while photocatalytic degradation of doxazosin aqueous solution has been carried out under constant oxygen flow. DOX degradation was more efficient in the TiO2/UVA photocatalytic experiment than during photolytic processes (UVA and UVC, UVC-N2). LC-HRMS analyses with electrospray ionization allowed observing the formation of several major degradation products depending on the reaction conditions (presence or absence of oxygen, photocatalysis). The transformation products were identified based on exact mass measurements, isotopic distribution, and fragmentation pattern. Among them, dominated C17H21N5O3 and C17H23N5O4 (cleavage of the dioxane cycle), and C23H25N5O7 (hydroxylation). The detailed degradation pathway has been proposed. Toxicity testing with V. fischeri luminescent bacteria revealed higher toxicity of samples in photolytic rather than photocatalytic experiments which might be attributed to the formation of different products.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ivana Tartaro Bujak (autor)

Citiraj ovu publikaciju

Tartaro Bujak, Ivana; Bavcon Kralj, Mojca; Kosyakov, Dmitry S.; Ul'yanovskii, Nikolay V.; Lebedev, Albert T.; Trebše, Polonca
Photolytic and photocatalytic degradation of doxazosin in aqueous solution // Science of the total environment, 740 (2020), 140131, 8 doi:10.1016/j.scitotenv.2020.140131 (međunarodna recenzija, članak, znanstveni)
Tartaro Bujak, I., Bavcon Kralj, M., Kosyakov, D., Ul'yanovskii, N., Lebedev, A. & Trebše, P. (2020) Photolytic and photocatalytic degradation of doxazosin in aqueous solution. Science of the total environment, 740, 140131, 8 doi:10.1016/j.scitotenv.2020.140131.
@article{article, year = {2020}, pages = {8}, DOI = {10.1016/j.scitotenv.2020.140131}, chapter = {140131}, keywords = {Doxazosin, Photolysis, Photocatalysis, LC-MS, Toxicity}, journal = {Science of the total environment}, doi = {10.1016/j.scitotenv.2020.140131}, volume = {740}, issn = {0048-9697}, title = {Photolytic and photocatalytic degradation of doxazosin in aqueous solution}, keyword = {Doxazosin, Photolysis, Photocatalysis, LC-MS, Toxicity}, chapternumber = {140131} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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