Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1069175

SARS-CoV-2 dissemination through peripheral nerves explains multiple organ injury


Fenrich, Matija; Mrđenović, Stefan; Balog, Marta; Tomić, Svetlana; Zjalić, Milorad; Rončević, Alen; Mandić, Dario; Debeljak, Željko; Heffer, Marija
SARS-CoV-2 dissemination through peripheral nerves explains multiple organ injury // Frontiers in Cellular Neuroscience, 14 (2020), 553241, 22 doi:10.3389/fncel.2020.00229 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1069175 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
SARS-CoV-2 dissemination through peripheral nerves explains multiple organ injury

Autori
Fenrich, Matija ; Mrđenović, Stefan ; Balog, Marta ; Tomić, Svetlana ; Zjalić, Milorad ; Rončević, Alen ; Mandić, Dario ; Debeljak, Željko ; Heffer, Marija

Izvornik
Frontiers in Cellular Neuroscience (1662-5102) 14 (2020); 553241, 22

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
SARS-CoV-2 ; Neurotropic infection ; Axonal Transport ; Peripheral Nerves ; Neurological symptoms ; Multiple organ damage

Sažetak
Coronavirus infectious disease (CoVID-19), caused by recently identified coronavirus SARS- CoV-2, is characterized by inconsistent clinical presentations. While many infected individuals remain asymptomatic or show mild respiratory symptoms, others develop severe pneumonia or even respiratory distress syndrome. So far, SARS-CoV-2 is reported to be able to infect lungs, intestines, blood vessels, bile ducts, conjunctiva, macrophages, T lymphocytes, heart, liver, kidneys and the brain. More than a third of cases displayed neurological involvement, and in many severely ill patients, multiple organ injury and infection was documented. However, less than 1% of patients had a detectable level of SARS-CoV- 2 in the blood, raising a question of how the virus spreads throughout the body. We propose that nerve terminals in orofacial mucosa, eyes and olfactory neuroepithelium act as entry points for the brain invasion, allowing SARS- CoV-2 to infect the brainstem. By exploiting the subcellular membrane compartments of infected cells, a feature common to all coronaviruses, SARS-CoV-2 is capable to disseminate from the brain to periphery via vesicular axonal transport and passive diffusion through axonal endoplasmic reticula, causing multiple organ injury independently of an underlying respiratory infection. The proposed model clarifies a wide range of clinically observed phenomena in CoVID-19 patients, such as neurological symptoms unassociated with lung pathology, findings of protracted presence of the virus in samples obtained from recovered patients, exaggerated immune response, multiple organ failure in severe cases with variable course and dynamics of the disease. The proposed model provides novel insights into CoVID-19 and its potential long-term sequelae, and establishes a framework for further investigations.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-2324 - Patofiziološke posljedice promjena sastava lipidnih splavi (HRZZ)

Ustanove
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek,
Sveučilište J. J. Strossmayera u Osijeku

Citiraj ovu publikaciju

Fenrich, Matija; Mrđenović, Stefan; Balog, Marta; Tomić, Svetlana; Zjalić, Milorad; Rončević, Alen; Mandić, Dario; Debeljak, Željko; Heffer, Marija
SARS-CoV-2 dissemination through peripheral nerves explains multiple organ injury // Frontiers in Cellular Neuroscience, 14 (2020), 553241, 22 doi:10.3389/fncel.2020.00229 (međunarodna recenzija, članak, znanstveni)
Fenrich, M., Mrđenović, S., Balog, M., Tomić, S., Zjalić, M., Rončević, A., Mandić, D., Debeljak, Ž. & Heffer, M. (2020) SARS-CoV-2 dissemination through peripheral nerves explains multiple organ injury. Frontiers in Cellular Neuroscience, 14, 553241, 22 doi:10.3389/fncel.2020.00229.
@article{article, year = {2020}, pages = {22}, DOI = {10.3389/fncel.2020.00229}, chapter = {553241}, keywords = {SARS-CoV-2, Neurotropic infection, Axonal Transport, Peripheral Nerves, Neurological symptoms, Multiple organ damage}, journal = {Frontiers in Cellular Neuroscience}, doi = {10.3389/fncel.2020.00229}, volume = {14}, issn = {1662-5102}, title = {SARS-CoV-2 dissemination through peripheral nerves explains multiple organ injury}, keyword = {SARS-CoV-2, Neurotropic infection, Axonal Transport, Peripheral Nerves, Neurological symptoms, Multiple organ damage}, chapternumber = {553241} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font