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Pregled bibliografske jedinice broj: 1068199

Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia


Nikolac Perkovic, Matea; Sagud, Marina; Zivkovic, Maja; Uzun, Suzana; Nedic Erjavec, Gordana; Kozumplik, Oliver; Svob Strac, Dubravka; Mimica, Ninoslav; Mihaljevic Peles, Alma; Pivac, Nela
Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia // Scientific reports, 10 (2020), 1; 10049, 11 doi:10.1038/s41598-020-67351-5 (međunarodna recenzija, članak, znanstveni)


Naslov
Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia

Autori
Nikolac Perkovic, Matea ; Sagud, Marina ; Zivkovic, Maja ; Uzun, Suzana ; Nedic Erjavec, Gordana ; Kozumplik, Oliver ; Svob Strac, Dubravka ; Mimica, Ninoslav ; Mihaljevic Peles, Alma ; Pivac, Nela

Izvornik
Scientific reports (2045-2322) 10 (2020), 1; 10049, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Catechol-O-methyltransferase ; rs4680 ; rs4818 ; haplotype ; association ; treatment response ; olanzapine ; patients ; schizophrenia

Sažetak
Antipsychotic drugs target primarily dopaminergic system which makes catechol-O-methyltransferase (COMT) an interesting target in studies searching for treatment response predictors in schizophrenia. The study assessed the association of the COMT rs4680 and rs4818 polymorphisms with therapeutic response to olanzapine, risperidone, clozapine or other antipsychotic medication after 8 weeks of monotherapy in patients with schizophrenia. 521 Caucasian patients with schizophrenia received a monotherapy with olanzapine (10–20 mg/day ; N = 190), risperidone (3–6 mg/day ; N = 99), or clozapine (100–500 mg/day ; N = 102). The fourth group (N = 130) consisted of patients receiving haloperidol (3–15 mg/day), fluphenazine (4–25 mg/day) or quetiapine (50–800 mg/day). Treatment response was defined as a 50% reduction from the baseline positive and negative syndrome scale (PANSS) total and subscale scores, but also as an observed percentage reduction from the initial PANSS0– 6 total and subscale scores. Carriers of the COMT rs4680 A allele and carriers of the COMT rs4680–rs4818 C-A haplotype block had greater reduction in the PANSS total scores following olanzapine treatment, compared to carriers of the COMT rs4680 GG genotype and other COMT rs4680–rs4818 haplotypes. The COMT rs4680 A allele, and COMT rs4680–rs4818 C-A haplotype, were significantly associated with therapeutic response in patients treated with olanzapine, but not in patients treated with other antipsychotics.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
This work has been supported by the project sponsored by the University of Zagreb, Croatia “Predictors of treatment response in schizophrenia”, BM1.45, PI: Marina Sagud ; and by the project sponsored by Ministry of Sciences and Education “Molecular basis and treatment of psychiatric and stress related disorders” No. 098-0982522-2455, PI: Nela Pivac.



POVEZANOST RADA


Projekt / tema
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Nela Pivac, )
BM1.45

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek,
Sveučilište u Zagrebu,
Sveučilište J. J. Strossmayera u Osijeku

Citiraj ovu publikaciju

Nikolac Perkovic, Matea; Sagud, Marina; Zivkovic, Maja; Uzun, Suzana; Nedic Erjavec, Gordana; Kozumplik, Oliver; Svob Strac, Dubravka; Mimica, Ninoslav; Mihaljevic Peles, Alma; Pivac, Nela
Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia // Scientific reports, 10 (2020), 1; 10049, 11 doi:10.1038/s41598-020-67351-5 (međunarodna recenzija, članak, znanstveni)
Nikolac Perkovic, M., Sagud, M., Zivkovic, M., Uzun, S., Nedic Erjavec, G., Kozumplik, O., Svob Strac, D., Mimica, N., Mihaljevic Peles, A. & Pivac, N. (2020) Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia. Scientific reports, 10 (1), 10049, 11 doi:10.1038/s41598-020-67351-5.
@article{article, year = {2020}, pages = {11}, DOI = {10.1038/s41598-020-67351-5}, chapter = {10049}, keywords = {Catechol-O-methyltransferase, rs4680, rs4818, haplotype, association, treatment response, olanzapine, patients, schizophrenia}, journal = {Scientific reports}, doi = {10.1038/s41598-020-67351-5}, volume = {10}, number = {1}, issn = {2045-2322}, title = {Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia}, keyword = {Catechol-O-methyltransferase, rs4680, rs4818, haplotype, association, treatment response, olanzapine, patients, schizophrenia}, chapternumber = {10049} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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