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Pregled bibliografske jedinice broj: 1068199

Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia


Nikolac Perković, Matea; Šagud, Marina; Živković, Maja; Uzun, Suzana; Nedić Erjavec, Gordana; Kozumplik, Oliver; Švob Štrac, Dubravka; Mimica, Ninoslav; Mihaljević Peleš, Alma; Pivac, Nela
Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia // Scientific reports, 10 (2020), 1; 10049, 11 doi:10.1038/s41598-020-67351-5 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1068199 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia

Autori
Nikolac Perković, Matea ; Šagud, Marina ; Živković, Maja ; Uzun, Suzana ; Nedić Erjavec, Gordana ; Kozumplik, Oliver ; Švob Štrac, Dubravka ; Mimica, Ninoslav ; Mihaljević Peleš, Alma ; Pivac, Nela

Izvornik
Scientific reports (2045-2322) 10 (2020), 1; 10049, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Catechol-O-methyltransferase ; rs4680 ; rs4818 ; haplotype ; association ; treatment response ; olanzapine ; patients ; schizophrenia

Sažetak
Antipsychotic drugs target primarily dopaminergic system which makes catechol-O-methyltransferase (COMT) an interesting target in studies searching for treatment response predictors in schizophrenia. The study assessed the association of the COMT rs4680 and rs4818 polymorphisms with therapeutic response to olanzapine, risperidone, clozapine or other antipsychotic medication after 8 weeks of monotherapy in patients with schizophrenia. 521 Caucasian patients with schizophrenia received a monotherapy with olanzapine (10–20 mg/day ; N = 190), risperidone (3–6 mg/day ; N = 99), or clozapine (100–500 mg/day ; N = 102). The fourth group (N = 130) consisted of patients receiving haloperidol (3–15 mg/day), fluphenazine (4–25 mg/day) or quetiapine (50–800 mg/day). Treatment response was defined as a 50% reduction from the baseline positive and negative syndrome scale (PANSS) total and subscale scores, but also as an observed percentage reduction from the initial PANSS0– 6 total and subscale scores. Carriers of the COMT rs4680 A allele and carriers of the COMT rs4680–rs4818 C-A haplotype block had greater reduction in the PANSS total scores following olanzapine treatment, compared to carriers of the COMT rs4680 GG genotype and other COMT rs4680–rs4818 haplotypes. The COMT rs4680 A allele, and COMT rs4680–rs4818 C-A haplotype, were significantly associated with therapeutic response in patients treated with olanzapine, but not in patients treated with other antipsychotics.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
BM1.45
MZOS-098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek,
Sveučilište J. J. Strossmayera u Osijeku

Citiraj ovu publikaciju:

Nikolac Perković, Matea; Šagud, Marina; Živković, Maja; Uzun, Suzana; Nedić Erjavec, Gordana; Kozumplik, Oliver; Švob Štrac, Dubravka; Mimica, Ninoslav; Mihaljević Peleš, Alma; Pivac, Nela
Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia // Scientific reports, 10 (2020), 1; 10049, 11 doi:10.1038/s41598-020-67351-5 (međunarodna recenzija, članak, znanstveni)
Nikolac Perković, M., Šagud, M., Živković, M., Uzun, S., Nedić Erjavec, G., Kozumplik, O., Švob Štrac, D., Mimica, N., Mihaljević Peleš, A. & Pivac, N. (2020) Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia. Scientific reports, 10 (1), 10049, 11 doi:10.1038/s41598-020-67351-5.
@article{article, author = {Nikolac Perkovi\'{c}, Matea and \v{S}agud, Marina and \v{Z}ivkovi\'{c}, Maja and Uzun, Suzana and Nedi\'{c} Erjavec, Gordana and Kozumplik, Oliver and \v{S}vob \v{S}trac, Dubravka and Mimica, Ninoslav and Mihaljevi\'{c} Pele\v{s}, Alma and Pivac, Nela}, year = {2020}, pages = {11}, DOI = {10.1038/s41598-020-67351-5}, chapter = {10049}, keywords = {Catechol-O-methyltransferase, rs4680, rs4818, haplotype, association, treatment response, olanzapine, patients, schizophrenia}, journal = {Scientific reports}, doi = {10.1038/s41598-020-67351-5}, volume = {10}, number = {1}, issn = {2045-2322}, title = {Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia}, keyword = {Catechol-O-methyltransferase, rs4680, rs4818, haplotype, association, treatment response, olanzapine, patients, schizophrenia}, chapternumber = {10049} }
@article{article, author = {Nikolac Perkovi\'{c}, Matea and \v{S}agud, Marina and \v{Z}ivkovi\'{c}, Maja and Uzun, Suzana and Nedi\'{c} Erjavec, Gordana and Kozumplik, Oliver and \v{S}vob \v{S}trac, Dubravka and Mimica, Ninoslav and Mihaljevi\'{c} Pele\v{s}, Alma and Pivac, Nela}, year = {2020}, pages = {11}, DOI = {10.1038/s41598-020-67351-5}, chapter = {10049}, keywords = {Catechol-O-methyltransferase, rs4680, rs4818, haplotype, association, treatment response, olanzapine, patients, schizophrenia}, journal = {Scientific reports}, doi = {10.1038/s41598-020-67351-5}, volume = {10}, number = {1}, issn = {2045-2322}, title = {Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia}, keyword = {Catechol-O-methyltransferase, rs4680, rs4818, haplotype, association, treatment response, olanzapine, patients, schizophrenia}, chapternumber = {10049} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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