Breast Cancer in Young Women: Pathologic and Immunohistochemical Features (CROSBI ID 279992)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Erić, Ivan ; Petek Erić, Anamarija ; Kristek, Jozo ; Koprivčić, Ivan ; Babić, Marko
engleski
Breast Cancer in Young Women: Pathologic and Immunohistochemical Features
A young woman with breast cancer is considered to be a woman younger than 40. According to the literature, breast cancer in the population of young women usually is of a higher histologic grade, unfavorable hormonal status, and overall higher mortality rate when compared with breast cancer occurring in the older population. We compared pathologic and immunohistochemical features of breast carcinoma in women under 40 years of age with the respective features in women over 60 years of age. The following parameters were observed in these two groups: tumor size, lymph node status, histologic grade, hormonal receptor status, Ki-67 prognostic index, Her2/neu status, and histologic type of the tumor. Early-onset breast carcinoma was found to have a higher frequency of tumor grade 3 (29% vs. 17%) and estrogen receptor negativity (45% vs. 23%). In the group of young women, breast carcinoma was mostly multicentric (23% vs. 5%), triple- negative (32% vs. 10%), and was found to have higher proliferation index Ki-67 (25% vs. 10%). Our results confirmed differences between the young and older groups of patients. In the group of young women, we found predominantly unfavorable prognostic parameters of the disease.
Breast neoplasms ; Female ; Lymph codes ; Croatia
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Podaci o izdanju
57 (3)
2018.
497-501
objavljeno
0353-9466
1333-9451
10.20471/acc.2018.57.03.13
Povezanost rada
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Kliničke medicinske znanosti