engleski

Independent factors of poor prognosis in young patients with breast cancer stage I- III

Introduction Breast cancer is the most common malignancy in the population of women under 40 years of age. Young age is the independent factor for poor prognosis. In this research, we tried to establish other factors for poor prognosis in breast cancer stage I- III. Materials and methods The following parameters were observed: tumor size, lymph node status, histological grade, hormonal receptor status, Ki-67 prognostic index, Her2 neu status histological type of the tumor, local recurrence, and metastases. Logistic regression has been used to evaluate the influence of specific factors on the probability of a deadly outcome and the development of distant metastases. Results Our patients were found to have the predominance of tumor T1 (49, 4%), had positive lymph nodes (62%), most of them were pN1 61, 2%. Up to one-third of patients have had triple- negative status. Ki-67 proliferation index was high 25%. We have found an incidence of multicentric tumors in 23% of patients. There was no difference in OS between two types of surgical procedures. Patients with pN0 status have had better OS. Conclusion Breast cancer in the population of young women has a more aggressive nature. The Independent factor of poor prognosis of breast cancer stage I- III is positive lymph node status.

Breast cancer, Young women, Multivariate analysis, Independent risk factor

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