engleski

Analysis of axillary lymph nodes in breast cancer patients with positive sentinel lymph node biopsy

Objective: The aim of this study was to show the incidence of patient with positive non-SLN after the axillar dissection was performed due to positive SLN and also to show haw the incidence of positive non-SLN depend on penetration of sentinel's capsule by malignant cells, gradus and molecular subtype of the breast cancer. Methods: This research has analysed 77 patients with a positive SLN in the period of five years and they have been categorized according to several criteria: positivity of the other axillary lymph nodes, affection of the sentinel’s capsule, the grade of the tumor and its T stadium and the molecular subtype of the tumor. Results: In over 65% of the patients the non- SLN were negative even the SLN was positive. There was a noticeable correlation between the penetration of the capsule of the SLN and the positive non-SLN (p<0, 001). It has also been confirmed that the non –SLN are more often positive in the patients with a high tumor grade, high T stadium and in patients with HER- 2 positive and triple negative tumors. Conclusion: The metastases in non-SLN are generally found in patients with the penetrated sentinel's capsule by malignant cells, in patients with low differentiated tumors (high grade) and in those with high T stage of the tumor as well as i triple negative and HER-2 positive tumors. According to these findings such patients when we expect metastases in non- SLN should be undergone to axillar dissection.

axillar dissection ; breast cancer ; positive sentinel lymph nod ; , radiotherapy ; surgery

nije evidentirano