Upalni markeri i učestalost drugih autoimunih bolesti u oboljelih od oralnoga lihena planusa (CROSBI ID 279908)
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Družijanić, Ana ; Glavina, Ana ; Draganja, Mirna ; Biočina-Lukenda, Dolores ; Cigić, Livia
hrvatski
Upalni markeri i učestalost drugih autoimunih bolesti u oboljelih od oralnoga lihena planusa
Sažetak Uvod: Oralni lihen planus (OLP) kronična je imunosna upalna bolest sluznice usne šupljine još nerazjašnjene etiologije. Materijali i metode: U istraživanju su sudjelovala 63 ispitanika s dijagnozom oralnoga lihena planusa i 63 bez patoloških promjena na oralnoj sluznici – oni su svrstani u kontrolnu skupinu. Svim ispitanicima uzeti su anamnestički podatci o prisutnosti druge autoimune bolesti te im je izvađen uzorak venske krvi za određivanje brzine sedimentacije (SE-a), broja leukocita (L-a) i koncentracije C-reaktivnog proteina u serumu (CRP-a). Statistička analiza: U statističkoj obradi korištene su metode deskriptivne statistike, χ2-test , Fisherov egzaktni test te Studentov t-test. Rezultati su interpretirani na razini značajnosti P < 0, 05. Rezultati: Za sva tri mjerena upalna markera nije bilo statistički značajne razlike u broju ispitanika s povišenim vrijednostima između ispitne i kontrolne skupine (P = 0, 364 za SE ; P = 1, 000 za CRP i P = 0, 219 za L). Promatrajući druge autoimune bolesti, statistički je značajno bila veća učestalost u ispitnoj skupini, a najčešće su to bili kožni lihen kod devet ispitanika (14, 29 %) i celijakija kod sedam (11, 11%). Zaključci: Rezultati su pokazali da nema značajne razlike u prosječnim vrijednostima ispitivanih upalnih markera u krvi između oboljelih od OLP-a i ispitanika u kontrolnoj skupini te je dokazana značajno veća učestalost drugih autoimunih bolesti kod oboljelih od OLP-a, najčešće kožni lihen i celijakija.
oralni lihen planus ; autoimuna bolest ; upala ; C-reaktivna bjelančevina
nije evidentirano
engleski
Inflammatory Markers and Incidence of other Autoimmune Diseases in Patients with Oral Lichen Planus
Oral lichen planus (OLP) is a chronic immune, inflammatory disease of the oral cavity of a still unknown etiology. Materials and methods: The study involved 63 subjects diagnosed with oral lichen planus and 63 subjects without pathologic changes in the oral mucosa who were classified as controls. All subjects were given a detailed medical history at first screening. The medical history of the presence of other autoimmune disease in all subjects was supported by medical records. A sample of venous blood was taken from each subject in order to determine sedimentation rate (SE) and leukocyte count (L) using standard laboratory procedures, and serum C-reactive protein (CRP) concentration values were determined as well. Statistical analysis: The methods of descriptive statistics, χ2-test, the Fisher’s exact test, and the Student’s t-test were used in the statistical processing of the results. The results were interpreted at a significance level of P <0.05. Results: For all three measured inflammatory markers, there were no statistically significant differences in the number of subjects with elevated values between the test and control groups (P = 0.364 for SE; P = 1.000 for CRP and P = 0.219 for L). The prevalence of other autoimmune disease in the OLP group was higher than in the control group, with statistical significance, and the most common was cutaneous lichen in nine subjects (14.29%) with OLP and celiac disease seven subjects (11.11%). Conclusions: The results showed that there was no significant difference in the average values of the investigated inflammatory markers in blood (SE, CRP and L) between patients with OLP and control subjects, while a significantly higher incidence of other autoimmune diseases in patients with OLP was demonstrated.
Oral Lichen Planus ; Autoimmune Disease ; Inflammation ; C-Reactive Protein
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