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Pregled bibliografske jedinice broj: 1067656

Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients


Dvojković, Anja; Nikolac Perković, Matea; Šagud, Marina; Nedić Erjavec, Gordana; Mihaljević Peleš, Alma; Švob Štrac, Dubravka; Vuksan Ćusa, Bjanka; Tudor, Lucija; Kušević, Zorana; Konjevod, Marcela et al.
Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients // Progress in neuro-psychopharmacology & biological psychiatry (2020) doi:10.1016/j.pnpbp.2020.110016 (znanstveni, prihvaćen)


Naslov
Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients

Autori
Dvojković, Anja ; Nikolac Perković, Matea ; Šagud, Marina ; Nedić Erjavec, Gordana ; Mihaljević Peleš, Alma ; Švob Štrac, Dubravka ; Vuksan Ćusa, Bjanka ; Tudor, Lucija ; Kušević, Zorana ; Konjevod, Marcela ; Živković, Maja ; Jevtović, Saša ; Pivac, Nela

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Progress in neuro-psychopharmacology & biological psychiatry (2020)

Status rada
Prihvaćen

Ključne riječi
depression ; escitalopram ; plasma BDNF ; platelet serotonin ; patients ; vortioxetine

Sažetak
Escitalopram and vortioxetine are efficacious antidepressants. They directly target serotonin (5-HT) system, but vortioxetine mechanism of action is distinct from the one of selective serotonin reuptake inhibitors (SSRIs). Treatment with SSRIs decrease platelet 5-HT concentration and increase peripheral brain- derived neurotrophic factor (BDNF) levels. Since vortioxetine has a multimodal mechanism of action, it is expected to have a greater effect on circulatory BDNF concentration, compared to conventional antidepressants. This longitudinal study aimed to explore and compare the effects of 4-weeks of treatment with vortioxetine and escitalopram on plasma BDNF and platelet 5-HT concentration in patients with major depressive disorder (MDD). The results revealed that vortioxetine significantly increased plasma BDNF concentration (p=0.018) and significantly decreased platelet 5-HT concentration (p<0.001). Treatment with escitalopram significantly decreased platelet 5-HT concentration (p <0.001), but it did not affect plasma BDNF concentration (p=0.379). Response to vortioxetine was not predicted by baseline plasma BDNF or platelet 5-HT concentration, but response to escitalopram was predicted by baseline platelet 5-HT concentration. These effects might be due to vortioxetine unique mechanism of action, but the clinical implications are unclear. It remains to be determined whether this finding extends during long-term vortioxetine treatment, and which, if any, clinical effects emerge from BDNF increase.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Dvojković, Anja; Nikolac Perković, Matea; Šagud, Marina; Nedić Erjavec, Gordana; Mihaljević Peleš, Alma; Švob Štrac, Dubravka; Vuksan Ćusa, Bjanka; Tudor, Lucija; Kušević, Zorana; Konjevod, Marcela et al.
Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients // Progress in neuro-psychopharmacology & biological psychiatry (2020) doi:10.1016/j.pnpbp.2020.110016 (znanstveni, prihvaćen)
Dvojković, A., Nikolac Perković, M., Šagud, M., Nedić Erjavec, G., Mihaljević Peleš, A., Švob Štrac, D., Vuksan Ćusa, B., Tudor, L., Kušević, Z. & Konjevod, M. (2020) Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients. Prihvaćen za objavljivanje u Progress in neuro-psychopharmacology & biological psychiatry. [Preprint] doi:10.1016/j.pnpbp.2020.110016.
@unknown{unknown, year = {2020}, DOI = {10.1016/j.pnpbp.2020.110016}, keywords = {depression, escitalopram, plasma BDNF, platelet serotonin, patients, vortioxetine}, journal = {Progress in neuro-psychopharmacology and biological psychiatry}, doi = {10.1016/j.pnpbp.2020.110016}, title = {Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients}, keyword = {depression, escitalopram, plasma BDNF, platelet serotonin, patients, vortioxetine} }

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