Lower urine uromodulin is associated with trend to lower sodium excretion in middle-aged subjects (CROSBI ID 691728)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Josipović, Josipa ; Šimičević, Livija ; Miličić, Borna ; Vrkić, Nada ; Boban, Marko ; Vrsalović, Mislav ; Pavlović, Nikola ; Bulj, Nikola ; Trbušić, Matias ; Delić-Brkljačić, Diana ; Jelaković, Bojan
engleski
Lower urine uromodulin is associated with trend to lower sodium excretion in middle-aged subjects
Objective: Recent GWAS studies found uromodulin gene polymorphisms to be associated with increased risk for hypertension (HT) and chronic kidney disease. It was hypothesized that relation of uromodulin with HT might be through effects on sodium renal excretion. Our aim was to analyse association of urinary uromodulin concentrations (uUMc) with blood pressure (BP) and sodium excretion in a group of untreated middle-aged subjects. Design and method: In this cross-sectional study 175 apparently healthy untreated subjects without a history for CV and with eGFR> 60 ml/min/1.73 m2 were enrolled. Fasting blood and urine 24-hour urine sample were obtained and BP was measured following ESH/ESC guidelines in office (Omron M6) and during regular working (ABPM: Mobile-O-Graph). Based on office BP subjects were divided according to the JNC-7 classification. Uromodulin was determined by Enzyme
uromodulin ; gene polymorphisms ; hypertension ; chronic kidney disease
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
e318-e318.
2019.
objavljeno
10.1097/01.hjh.0000573964.36817.b0
Podaci o matičnoj publikaciji
Journal of Hypertension
Los Angeles (CA): OMICS Publishing Group
2167-1095
2167-1095
Podaci o skupu
29th European Meeting on Hypertension and Cardiovascular Protection (ESH 2019)
poster
21.06.2019-24.06.2019
Milano, Italija