Feroptoza: regulirana stanična smrt (CROSBI ID 279780)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Čepelak, Ivana ; Dodig, Slavica ; Čepelak Dodig, Daniela
engleski
Feroptoza: regulirana stanična smrt
Ferroptosis is a recently identified form of regulated cell death that differs from other known forms of cell death morphologically, biochemically, and genetically. The main properties of ferroptosis are free redox-active iron and consequent iron-dependent peroxidation of polyunsaturated fatty acids in cell membrane phospholipids, which results in the accumulation of lipid-based reactive oxygen species due to loss of glutathione peroxidase 4 activity. Ferroptosis has increasingly been associated with neurodegenerative diseases, carcinogenesis, stroke, intracerebral haemorrhage, traumatic brain injury, and ischemia-reperfusion injury. It has also shown a significant therapeutic potential in the treatment of cancer and other diseases. This review summarises current knowledge about and the mechanisms that regulate ferroptosis.
glutathione peroxidase 4 ; lipid peroxidation ; reactive oxygen species ; system Xc- ; iron
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Podaci o izdanju
71 (2)
2020.
99-109
objavljeno
0004-1254
1848-6312
10.2478/aiht-2020-71-3366
Povezanost rada
Biologija, Farmacija, Kliničke medicinske znanosti, Temeljne medicinske znanosti