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Pregled bibliografske jedinice broj: 1067189

Sarcopenia among patients after allogeneic hematopoietic stem cell transplantation and the impact of chronic graft versus host disease


Ljubas Kelečić, Dina; Lelas, Antonela; Karas, Irena; Desnica, Lana; Vukić, Tamara; Sabol, Ivan; Vranešić Bender, Darija; Serventi Seiwerth, Ranka; Perić, Zinaida; Duraković, Nadira et al.
Sarcopenia among patients after allogeneic hematopoietic stem cell transplantation and the impact of chronic graft versus host disease // Journal of cancer research and clinical oncology (2020) doi:10.1007/s00432-020-03280-0 (znanstveni, prihvaćen)


Naslov
Sarcopenia among patients after allogeneic hematopoietic stem cell transplantation and the impact of chronic graft versus host disease

Autori
Ljubas Kelečić, Dina ; Lelas, Antonela ; Karas, Irena ; Desnica, Lana ; Vukić, Tamara ; Sabol, Ivan ; Vranešić Bender, Darija ; Serventi Seiwerth, Ranka ; Perić, Zinaida ; Duraković, Nadira ; Vitali Čepo, Dubravka ; Vrhovac, Radovan ; Nemet, Damir ; Pavletic, Steven ; Pulanić, Dražen ; Krznarić, Željko

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Journal of cancer research and clinical oncology (2020)

Status rada
Prihvaćen

Ključne riječi
Sarcopenia ; Allo-HSCT ; cGVHD ; Malnutrition ; Hand-grip strength ; Vitamin D

Sažetak
Purpose This study investigated the frequency and characteristics of sarcopenia among patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a specific focus on the chronic graft-versus-host disease (cGVHD) population and its association with malnutrition, vitamin D and clinical characteristics. Methods We assessed sarcopenia, vitamin D levels, and nutritional status in 73 patients who underwent allo-HSCT, of which 45 were diagnosed with cGVHD. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. Results Sarcopenia was diagnosed in 19.2% of patients after allo-HSCT with statistically no significant difference between cGVHD and non- cGVHD patients. The risk factor for sarcopenia was the male gender. Sarcopenia in allo-HSCT patients correlated strongly with malnutrition and with current corticosteroid treatment (p < 0.005). Among cGVHD patients sarcopenia additionally correlated strongly with the number of prior systemic immunosuppressive therapy lines (p < 0.005) and moderately with the intensity of immunosuppression, cGVHD severity global rating assessed by both the health care provider and the patient and joint and fascia cGVHD involvement (p < 0.05). Vitamin D deficiency was found in more than 54.8% of patients, but the correlation to sarcopenia was not found. Conclusion Sarcopenia was found to be common in long term survivors of allo-HSCT independently of the cGVHD diagnosis. Prospective longitudinal studies are needed for a better understanding of factors affecting the development of sarcopenia after allo-HSCT.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Ljubas Kelečić, Dina; Lelas, Antonela; Karas, Irena; Desnica, Lana; Vukić, Tamara; Sabol, Ivan; Vranešić Bender, Darija; Serventi Seiwerth, Ranka; Perić, Zinaida; Duraković, Nadira et al.
Sarcopenia among patients after allogeneic hematopoietic stem cell transplantation and the impact of chronic graft versus host disease // Journal of cancer research and clinical oncology (2020) doi:10.1007/s00432-020-03280-0 (znanstveni, prihvaćen)
Ljubas Kelečić, D., Lelas, A., Karas, I., Desnica, L., Vukić, T., Sabol, I., Vranešić Bender, D., Serventi Seiwerth, R., Perić, Z. & Duraković, N. (2020) Sarcopenia among patients after allogeneic hematopoietic stem cell transplantation and the impact of chronic graft versus host disease. Prihvaćen za objavljivanje u Journal of cancer research and clinical oncology. [Preprint] doi:10.1007/s00432-020-03280-0.
@unknown{unknown, year = {2020}, DOI = {10.1007/s00432-020-03280-0}, keywords = {Sarcopenia, Allo-HSCT, cGVHD, Malnutrition, Hand-grip strength, Vitamin D}, journal = {Journal of cancer research and clinical oncology}, doi = {10.1007/s00432-020-03280-0}, title = {Sarcopenia among patients after allogeneic hematopoietic stem cell transplantation and the impact of chronic graft versus host disease}, keyword = {Sarcopenia, Allo-HSCT, cGVHD, Malnutrition, Hand-grip strength, Vitamin D} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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