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Pregled bibliografske jedinice broj: 1066699

Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans


Sekovanić, Ankica; Jurasović, Jasna; Piasek, Martina
Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans // Arhiv za higijenu rada i toksikologiju, 71 (2020), 1; 27-47 doi:10.2478/aiht-2020-71-3349 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 1066699 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans

Autori
Sekovanić, Ankica ; Jurasović, Jasna ; Piasek, Martina

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 71 (2020), 1; 27-47

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
metals and metalloids ; rs28366003 ; rs10636 ; rs1610216 ; single nucleotide polymorphism

Sažetak
Human metallothioneins are a superfamily of low molecular weight intracellular proteins, whose synthesis can be induced by essential elements (primarily Zn and Cu), toxic elements and chemical agents, and stress-producing conditions. Of the four known isoforms in the human body MT2 is the most common. The expression of metallothioneins is encoded by a multigene family of linked genes and can be influenced by single nucleotide polymorphisms (SNPs) in these genes. To date, 24 SNPs in the MT2A gene have been identified with the incidence of about 1 % in various population groups, and three of them were shown to affect physiological and pathophysiological processes. This review summarises current knowledge about these three SNPs in the MT2A gene and their associations with element concentrations in the body of healthy and diseased persons. The most investigated SNP is rs28366003 (MT2A −5 A/G). Reports associate it with longevity, cancer (breast, prostate, laryngeal, and in paranasal sinuses), and chronic renal disease. The second most investigated SNP, rs10636 (MT2A +838G/C), is associated with breast cancer, cardiovascular disease, and type 2 diabetes. Both are also associated with several metal/metalloid concentrations in the organism. The third SNP, rs1610216 (MT2A −209A/G), has been studied for association with type 2 diabetes, cardiomyopathy, hyperglycaemia, and Zn concentrations. Metallothionein concentrations and MT2A polymorphisms have a potential to be used as biomarkers of metal exposure and clinical markers of a number of chronic diseases. This potential needs to be studied and verified in a large number of well-defined groups of participants (several hundreds and thousands) with a focus on particular physiological or pathological condition and taking into consideration other contributing factors, such as environmental exposure and individual genetic and epigenetic makeup.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
MZOS-022-0222148-2135 - Izloženost metalima i njihovi učinci u graviditetu i postnatalnom razdoblju (Piasek, Martina, MZOS ) ( POIROT)
HRZZ-IP-2016-06-1998 - Procjena svakodnevne izloženosti metalima i osobne osjetljivosti majke kao čimbenika razvojnoga podrijetla zdravlja i bolesti (METALORIGINS) (Piasek, Martina; Jurasović, Jasna, HRZZ - 2016-06) ( POIROT)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Martina Piasek (autor)

Avatar Url Ankica Sekovanić (autor)

Avatar Url Jasna Jurasović (autor)

Poveznice na cjeloviti tekst rada:

doi hrcak.srce.hr

Citiraj ovu publikaciju:

Sekovanić, Ankica; Jurasović, Jasna; Piasek, Martina
Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans // Arhiv za higijenu rada i toksikologiju, 71 (2020), 1; 27-47 doi:10.2478/aiht-2020-71-3349 (međunarodna recenzija, pregledni rad, znanstveni)
Sekovanić, A., Jurasović, J. & Piasek, M. (2020) Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans. Arhiv za higijenu rada i toksikologiju, 71 (1), 27-47 doi:10.2478/aiht-2020-71-3349.
@article{article, author = {Sekovani\'{c}, Ankica and Jurasovi\'{c}, Jasna and Piasek, Martina}, year = {2020}, pages = {27-47}, DOI = {10.2478/aiht-2020-71-3349}, keywords = {metals and metalloids, rs28366003, rs10636, rs1610216, single nucleotide polymorphism}, journal = {Arhiv za higijenu rada i toksikologiju}, doi = {10.2478/aiht-2020-71-3349}, volume = {71}, number = {1}, issn = {0004-1254}, title = {Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans}, keyword = {metals and metalloids, rs28366003, rs10636, rs1610216, single nucleotide polymorphism} }
@article{article, author = {Sekovani\'{c}, Ankica and Jurasovi\'{c}, Jasna and Piasek, Martina}, year = {2020}, pages = {27-47}, DOI = {10.2478/aiht-2020-71-3349}, keywords = {metals and metalloids, rs28366003, rs10636, rs1610216, single nucleotide polymorphism}, journal = {Arhiv za higijenu rada i toksikologiju}, doi = {10.2478/aiht-2020-71-3349}, volume = {71}, number = {1}, issn = {0004-1254}, title = {Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans}, keyword = {metals and metalloids, rs28366003, rs10636, rs1610216, single nucleotide polymorphism} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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