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Pregled bibliografske jedinice broj: 106642

Bone marrow immunoscintigraphy in haematological patients with pancytopenia: preliminary results


Huić, Dražen; Ivančević, Velimir; Aurer, Igor; Dodig, Damir; Nemet, Damir; Labar, Boris; Poropat, Mirjana; Munz, Dieter L.
Bone marrow immunoscintigraphy in haematological patients with pancytopenia: preliminary results // Nuclear medicine communications, 23 (2002), 8; 757-763 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 106642 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bone marrow immunoscintigraphy in haematological patients with pancytopenia: preliminary results

Autori
Huić, Dražen ; Ivančević, Velimir ; Aurer, Igor ; Dodig, Damir ; Nemet, Damir ; Labar, Boris ; Poropat, Mirjana ; Munz, Dieter L.

Izvornik
Nuclear medicine communications (0143-3636) 23 (2002), 8; 757-763

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
scintigrafija koštane srži; pancitopenija; antigranulocitna protutijela
(bone marrow scintigraphy; pancytopenia; antigranulocyte antibodies)

Sažetak
The aim of this study was to assess the clinical value of bone marrow immunoscintigraphy using the (99m)Tc labelled anti-NCA-95 antigranulocyte antibodies (AGAb) and of AGAb bone marrow uptake ratio (UR) in the initial diagnostic work-up of diseases with depression of the bone marrow. Twenty-four whole-body bone marrow scans were performed in 23 patients (11 women, 12 men ; median age 46 years, range 17-74 years) 5 h after i.v. injection of 370 MBq of AGAb. The UR was calculated from the posterior view drawing an irregular region of interest around the sacroiliac and a background areas. The mean UR in pancytopenic patients was 2.3+/-1.5 (range 0.3-5.8), thus being significantly lower (P=0.45 x 10(-6)) than the mean UR in a control group of 50 patients (mean UR 7.3+/-2.3 ; range 4.4-12.6) obtained previously. Considering patient age, there was no overlap between UR of pancytopenic patients and the respective normal ranges. The bone marrow appearance on scans seemed to be characteristic for the different haematological diseases investigated. In six patients with myelofibrosis, bone marrow scans demonstrated diffusely decreased bone marrow activity and prominent splenic uptake, possibly related to extramedullary haematopoiesis. In aplastic anaemia, highly reduced and patchy marrow uptake was observed in four patients (five scans), in one of them persisting even after blood cell counts had recovered to the near-normal range. In another two patients with aplastic anaemia, diffusely decreased bone marrow uptake was obtained. In patients with myeloid leukaemia, bone marrow patterns were almost normal probably because the target antigen is often expressed on neoplastic myeloid cells, too. Bone marrow extension was a common finding in these patients. There is an obvious differentiation between haematological patients with pancytopenia and normal subjects by means of AGAb bone marrow uptake ratio. The distinct patterns of AGAb distribution may be indicative for particular haematological diseases.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Dentalna medicina, Farmacija



POVEZANOST RADA


Projekt / tema
0108007
214007

Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Damir Dodig (autor)

Avatar Url Mirjana Poropat (autor)

Avatar Url Velimir Ivančević (autor)

Avatar Url Igor Aurer (autor)

Avatar Url Damir Nemet (autor)

Avatar Url Dražen Huić (autor)

Avatar Url Boris Labar (autor)

Citiraj ovu publikaciju

Huić, Dražen; Ivančević, Velimir; Aurer, Igor; Dodig, Damir; Nemet, Damir; Labar, Boris; Poropat, Mirjana; Munz, Dieter L.
Bone marrow immunoscintigraphy in haematological patients with pancytopenia: preliminary results // Nuclear medicine communications, 23 (2002), 8; 757-763 (međunarodna recenzija, članak, znanstveni)
Huić, D., Ivančević, V., Aurer, I., Dodig, D., Nemet, D., Labar, B., Poropat, M. & Munz, D. (2002) Bone marrow immunoscintigraphy in haematological patients with pancytopenia: preliminary results. Nuclear medicine communications, 23 (8), 757-763.
@article{article, year = {2002}, pages = {757-763}, keywords = {bone marrow scintigraphy, pancytopenia, antigranulocyte antibodies}, journal = {Nuclear medicine communications}, volume = {23}, number = {8}, issn = {0143-3636}, title = {Bone marrow immunoscintigraphy in haematological patients with pancytopenia: preliminary results}, keyword = {bone marrow scintigraphy, pancytopenia, antigranulocyte antibodies} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Chemical Abstracts
  • Excerpta Medica
  • Index Medicus
  • SCIexp