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Pregled bibliografske jedinice broj: 1066107

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases


Klarić, Lucija; Tsepilov, Yakov A.; Stanton, Chloe M.; Mangino, Massimo; Sikka, Timo Tõnis; Esko, Tõnu; Pakhomov, Eugene; Salo, Perttu; Deelen, Joris; McGurnaghan, Stuart J. et al.
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases // Science Advances, 6 (2020), 8; eaax0301, 18 doi:10.1126/sciadv.aax0301 (međunarodna recenzija, članak, ostalo)


CROSBI ID: 1066107 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Autori
Klarić, Lucija ; Tsepilov, Yakov A. ; Stanton, Chloe M. ; Mangino, Massimo ; Sikka, Timo Tõnis ; Esko, Tõnu ; Pakhomov, Eugene ; Salo, Perttu ; Deelen, Joris ; McGurnaghan, Stuart J. ; Keser, Toma ; Vučković, Frano ; Ugrina, Ivo ; Krištić, Jasminka ; Gudelj, Ivan ; Štambuk, Jerko ; Plomp, Rosina ; Pučić-Baković, Maja ; Pavić, Tamara ; Vilaj, Marija ; Trbojević- Akmačić, Irena ; Drake, Camilla ; Dobrinić, Paula ; Mlinarec, Jelena ; Jelušić, Barbara ; Richmond, Anne ; Timofeeva, Maria ; Grishchenko, Alexander K. ; Dmitrieva, Julia ; Bermingham, Mairead L. ; Sharapov, Sodbo Zh. ; Farrington, Susan M. ; Theodoratou, Evropi ; Uh, Hae-Won ; Beekman, Marian ; Slagboom, Eline P. ; Louis, Edouard ; Georges, Michel ; Wuhrer, Manfred ; Colhoun, Helen M. ; Dunlop, Malcolm G. ; Perola, Markus ; Fischer, Krista ; Polasek, Ozren ; Campbell, Harry ; Rudan, Igor ; Wilson, James F. ; Zoldoš, Vlatka ; Vitart, Veronique ; Spector, Tim ; Aulchenko, Yurii S. ; Lauc, Gordan ; Hayward, Caroline

Izvornik
Science Advances (2375-2548) 6 (2020), 8; Eaax0301, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
immunoglobulin G ; glycosylation ; GWAS ; glycogenes ; inflammatory diseases

Sažetak
Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been observed in many diseases, but little is understood about the underlying mechanisms. We performed a genome-wide association study of IgG N-glycosylation (N = 8090) and, using a data-driven network approach, suggested how associated loci form a functional network. We confirmed in vitro that knockdown of IKZF1 decreases the expression of fucosyltransferase FUT8, resulting in increased levels of fucosylated glycans, and suggest that RUNX1 and RUNX3, together with SMARCB1, regulate expression of glycosyltransferase MGAT3. We also show that variants affecting the expression of genes involved in the regulation of glycoenzymes colocalize with variants affecting risk for inflammatory diseases. This study provides new evidence that variation in key transcription factors coupled with regulatory variation in glycogenes modifies IgG glycosylation and has influence on inflammatory diseases.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
GENOS d.o.o.

Citiraj ovu publikaciju

Klarić, Lucija; Tsepilov, Yakov A.; Stanton, Chloe M.; Mangino, Massimo; Sikka, Timo Tõnis; Esko, Tõnu; Pakhomov, Eugene; Salo, Perttu; Deelen, Joris; McGurnaghan, Stuart J. et al.
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases // Science Advances, 6 (2020), 8; eaax0301, 18 doi:10.1126/sciadv.aax0301 (međunarodna recenzija, članak, ostalo)
Klarić, L., Tsepilov, Y., Stanton, C., Mangino, M., Sikka, T., Esko, T., Pakhomov, E., Salo, P., Deelen, J. & McGurnaghan, S. (2020) Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases. Science Advances, 6 (8), eaax0301, 18 doi:10.1126/sciadv.aax0301.
@article{article, year = {2020}, pages = {18}, DOI = {10.1126/sciadv.aax0301}, chapter = {eaax0301}, keywords = {immunoglobulin G, glycosylation, GWAS, glycogenes, inflammatory diseases}, journal = {Science Advances}, doi = {10.1126/sciadv.aax0301}, volume = {6}, number = {8}, issn = {2375-2548}, title = {Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases}, keyword = {immunoglobulin G, glycosylation, GWAS, glycogenes, inflammatory diseases}, chapternumber = {eaax0301} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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