engleski

Genetic polymorphism of paraoxonase related to myocardial infarction in Croatian population

Recent studies have implicated paraoxonase (PON1), an HDL associated enzyme, in providing protection against LDL oxidation, thus affecting the risk of coronary heart disease (CHD). The genetic polymorphism at codone 192 of PON1 has been suggested to contribute to the development of CHD and atherosclerosis. Since data in the literature on the association of PON1 polymorphism and the occurrence of myocardial infarction (MI) are still contraversial, therefore we have performed a study to evaluate relationship between PON1 genotypes in 200 patients who suffered from MI and 200 randomly selected healthy volunteers. Our results showed no statistically significant difference for allele frequencies between investigated groups. Genotype frequencies were 52.6, 37.0, 10.4 in MI patients and 48.8, 49.2 and 4.0 in controls for AA, AB and BB genotypes respectively. Both groups differed significantly (p<0.008) with more common BB genotype in MI patients. The risk for MI (odds ratio) for BB carriers was 2.8 (95% CI 1.25-6.33). Enzymatic activities differed significantly (p<0.004) between patient group and previously measured activities for 146 healthy controls. These data indicate that a common polymorphism in the paraoxonase BB genotype may represent and independent genetic risk factor for myocardial infarction in Croatian population.

paraoxonase; HDL; LDL; coronary heart disease; atherosclerosis; myocardial infarction

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