engleski

Diels-Alder Reaction (Part 2)

Following more fundamental aspects presented in the first part, the second part of Special Issue on Diels-Alder cycloadditions emphasizes their applications in various fields of organic chemistry. For instance, Porée and Chirkin select examples of natural product total synthesis involving a Diels- Alder reaction and outline the diversity oriented synthesis of secondary metabolites. Interesting tandem Diels-Alder/sigmatropic rearrangement reactions with their applications to the synthesis of natural products is reviewed by Neier. The processes presented here present new strategic disconnections accessible via highlighted synthetic schemes. An overview of the versatile applications of the Diels-Alder cycloadditions in medicinal chemistry is provided by Bouchez, Rusch and Larraufie. Laclef covers the synthesis of carbohydrates and their analogs by Diels-Alder cycloadditions as well as the use of monosaccharides as sources of chirality in stereoselective Diels-Alder reactions. The use of this cycloaddition reactions for the construction of bridged bicyclic systems is described by Moreno-Vargas. Herein, the interesting applications of (7-hetero)norbornadienes as templates for the synthesis of biologically active products are reported. Finally, implication of a putative Diels-Alder reaction in the biosynthesis of natural products is presented by Cottet, Lallemand and Markovi. An overview of natural products that are considered to be biosynthesized by a Diels- Alderase-type of enzymes together with the putative biosynthetic pathways is summarized. This Special Issue is an outcome of the researchers from five different countries and it is alive witness of the intriguing research in the field of Diels-Alder reaction. We, thus, expect that a Special Issue dedicated to this wonderful reaction will inspire and stimulate the creativity of many chemists around the world and help to open new avenues that still remain to be discovered.

Diels Alder reaction, cycloadditions, mechanistic studies

nije evidentirano