engleski

The effect of magnesium alloy WE43 structure caused by equal channel angular pressing on the mechanical properties and the cytotoxicity to tumor cells in vitro

In this study, a degradable magnesium alloy WE43 was subjected to equal channel angular pressing (ECAP). Grain refi nement down to 0.7 – 1 μm and a transformation of texture induced by ECAP were shown to lead to increased the ultimate tensile strength (up to 300 MPa) combined with enhanced ductility (13.2%). The data presented show that co-incubation of tumor LNCaP and MDA-MB-231 cells with the WE43 alloy led to a decrease of their viability and proliferation. It was established that ECAP led to enhancement of the alloy cytotoxic activity against tumor cells. This study demonstrated that alloy WE43 can be considered as a promising candidate for application in orthopedic implants in clinical oncology.

magnesium alloy ; tumor cells ; in vitro

Konferencija je otkazana zbog pandemije COVID-19, ali su svi konferencijski materijali objavljeni.