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Pregled bibliografske jedinice broj: 1064817

Biodegradation of 1,2,3-Trichloropropane to Valuable (S)-2,3-DCP Using a One-Pot Reaction System


Bogale, Tadesse Fantaye; Gul, Ijaz; Wang, Le; Deng, Jiao; Chen, Yong; Majerić Elenkov, Maja; Tang, Lixia
Biodegradation of 1,2,3-Trichloropropane to Valuable (S)-2,3-DCP Using a One-Pot Reaction System // Catalysts, 10 (2020), 1; 3, 11 doi:10.3390/catal10010003 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1064817 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Biodegradation of 1,2,3-Trichloropropane to Valuable (S)-2,3-DCP Using a One-Pot Reaction System

Autori
Bogale, Tadesse Fantaye ; Gul, Ijaz ; Wang, Le ; Deng, Jiao ; Chen, Yong ; Majerić Elenkov, Maja ; Tang, Lixia

Izvornik
Catalysts (2073-4344) 10 (2020), 1; 3, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
immobilized dehalogenases ; 1, 2, 3-trichloropropane ; enantiopure compound ; one-pot reaction ; in-situ product removal

Sažetak
1, 2, 3-trichloropropane (TCP) being one of the important environmental pollutants, has drawn significant concern due to its highly toxic and carcinogenic effects. In this study, we built a one-pot reaction system in which immobilized haloalkane dehalogenase (DhaA31) and halohydrin dehalognase (HheC) were used to catalyze the recalcitrant TCP to produce 2, 3-dichloro-1-propanol (2, 3-DCP) by removing epichlorohydrin (ECH). SinceHheCdisplays a highRenantiopreference toward 2, 3-DCP, the production of enantiopure (S)-2, 3-DCP was expected. However, the enantioselective resolution of (R, S)-2, 3-DCP by HheC was greatly inhibited by the circular reaction occurring between the product ECH and 1, 3-dichloro-2-propanol (1.3-DCP). To resolve this problem, HZD-9 resin-based in situ product removal was implemented. Under the optimized conditions, TCP was completely consumed, resulting in optically pure (S)-2, 3-DCP with enantiomer excess (e.e) > 99% and 40% yield (out of the 44% theoretical maximum). The scale-up resin-integrated reaction system was successfully carried out in 0.5 L batch reactor. Moreover, the system could be reused for 6 rounds with 64% of original activity retained, showing that it could be applied in the treatment of large volumes of liquid waste and producing enantiopure (S)-2, 3-DCP.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Maja Majerić-Elenkov (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com fulir.irb.hr doi.org

Citiraj ovu publikaciju:

Bogale, Tadesse Fantaye; Gul, Ijaz; Wang, Le; Deng, Jiao; Chen, Yong; Majerić Elenkov, Maja; Tang, Lixia
Biodegradation of 1,2,3-Trichloropropane to Valuable (S)-2,3-DCP Using a One-Pot Reaction System // Catalysts, 10 (2020), 1; 3, 11 doi:10.3390/catal10010003 (međunarodna recenzija, članak, znanstveni)
Bogale, T., Gul, I., Wang, L., Deng, J., Chen, Y., Majerić Elenkov, M. & Tang, L. (2020) Biodegradation of 1,2,3-Trichloropropane to Valuable (S)-2,3-DCP Using a One-Pot Reaction System. Catalysts, 10 (1), 3, 11 doi:10.3390/catal10010003.
@article{article, year = {2020}, pages = {11}, DOI = {10.3390/catal10010003}, chapter = {3}, keywords = {immobilized dehalogenases, 1, 2, 3-trichloropropane, enantiopure compound, one-pot reaction, in-situ product removal}, journal = {Catalysts}, doi = {10.3390/catal10010003}, volume = {10}, number = {1}, issn = {2073-4344}, title = {Biodegradation of 1,2,3-Trichloropropane to Valuable (S)-2,3-DCP Using a One-Pot Reaction System}, keyword = {immobilized dehalogenases, 1, 2, 3-trichloropropane, enantiopure compound, one-pot reaction, in-situ product removal}, chapternumber = {3} }
@article{article, year = {2020}, pages = {11}, DOI = {10.3390/catal10010003}, chapter = {3}, keywords = {immobilized dehalogenases, 1, 2, 3-trichloropropane, enantiopure compound, one-pot reaction, in-situ product removal}, journal = {Catalysts}, doi = {10.3390/catal10010003}, volume = {10}, number = {1}, issn = {2073-4344}, title = {Biodegradation of 1,2,3-Trichloropropane to Valuable (S)-2,3-DCP Using a One-Pot Reaction System}, keyword = {immobilized dehalogenases, 1, 2, 3-trichloropropane, enantiopure compound, one-pot reaction, in-situ product removal}, chapternumber = {3} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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