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Pregled bibliografske jedinice broj: 10638

Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue


Šimaga, Šumski; Babić, Damir; Osmak, Maja; Ilić-Forko, Jadranka; Vitale, Ljubinka; Miličić, Duško; Abramić, Marija
Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue // European journal of cancer (1990), 34 (1998), 3; 399-405 (međunarodna recenzija, članak, znanstveni)


Naslov
Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue

Autori
Šimaga, Šumski ; Babić, Damir ; Osmak, Maja ; Ilić-Forko, Jadranka ; Vitale, Ljubinka ; Miličić, Duško ; Abramić, Marija

Izvornik
European journal of cancer (1990) (0959-8049) 34 (1998), 3; 399-405

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dipeptidyl peptidase III; human uterus; human ovary; endometrial cancer; ovarian cancer

Sažetak
Exopeptidases, in contrast to endopeptidases (proteinases) have been much less studied in relation to cancer. The aim of this study was to investigate one such enzyme, dipeptidyl peptidase III (DPP III), in gynaecological tissues, by measuring both the enzyme activity and enzyme content. DPP III activity was assessed in normal (n=65), benign (n=9) and malignant (n=51) gynaecological tissues. A statistically significant higher DPP III activity was observed in endometrial (n=40), P=4.6x10^-7) and ovarian (n=11, P=8.5x10^-4) malignant tumours, whereas no significant difference was detected for leiomyomas (n=8), if compared to the activity in normal tissue. A matched pair analysis of normal and cancerous endometrial tissue confirmed the significance of the DPP III activity increase in the transformed tissue (n=7, P=0.022). Western blot analysis revealed a significantly (P=0.014) increased level of DPP III in endometrial cancer. Further, regression analysis showed a positive correlation between the activity and the content of DPP III in normal tissue (r=0.637, P=0.047) and in endometrial cancer (r=0.574, P<0.007). The increase of the DPP III activity was observed in the endometrial carcinomas of various histological types, grade or the depth of myometrial invasion. The easy-to-perform determination of this exopeptidase activity may serve as a potential indicator of endometrial and ovariamn malignancies.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekt / tema
00980705
00981008
108097

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Šimaga, Šumski; Babić, Damir; Osmak, Maja; Ilić-Forko, Jadranka; Vitale, Ljubinka; Miličić, Duško; Abramić, Marija
Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue // European journal of cancer (1990), 34 (1998), 3; 399-405 (međunarodna recenzija, članak, znanstveni)
Šimaga, Š., Babić, D., Osmak, M., Ilić-Forko, J., Vitale, L., Miličić, D. & Abramić, M. (1998) Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue. European journal of cancer (1990), 34 (3), 399-405.
@article{article, year = {1998}, pages = {399-405}, keywords = {dipeptidyl peptidase III, human uterus, human ovary, endometrial cancer, ovarian cancer}, journal = {European journal of cancer (1990)}, volume = {34}, number = {3}, issn = {0959-8049}, title = {Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue}, keyword = {dipeptidyl peptidase III, human uterus, human ovary, endometrial cancer, ovarian cancer} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE