engleski

The use of BMPs in children.

Numerous animal studies and clinical testing of rhBMP-7in humans have shown improvement in bone healing and repair in tibial non-unions and fresh fracture model. However, use of BMPs in children has not been considered in the past, because unknown influence on local growth plate and the possibility of unpredicted reactions in growing skeleton on occasion of tumor occurrence. Congenital pseudarthrosis of the tibia (CPT) is a rare and frustrating disease due to multiple unsuccessful surgeries and eventual amputation. Recently, a few papers reported on the application of rhBMPs-7 in children as adjuvant to standard treatment options. Controversies in clinical application of BMP in children are pointed out.

Bone morphogenetic protein ; children ; application

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