engleski

Brain tissue volumes at term-equivalent age are associated with early motor behavior in very preterm infants

Preterm birth is associated with a wide range of adverse developmental outcomes, including sensory, motor, cognitive and language impairments, and behavioral or attention problems. Subtle motor deficits that might emerge in premature infants with no evident or with mild brain injury encompass qualitative and quantitative aspects of motor behavior. This prospective cohort study provided evaluation of the relationship between brain tissue volumes revealed by magnetic resonance imaging (MRI) at term- equivalent age (TEA) and motor behavior in infancy in very preterm infants (total number=40 ; mean gestational age=28weeks+4days ; mean birthweight=1190g) without evident or with mild brain injury. Infants were recruited at birth and assessed at 12 months corrected age (CA) using the tool for qualitative and quantitative assessment of motor behavior, Infant Motor Profile (IMP). The brain tissue was segmented first Accepted Article This article is protected by copyright. All rights reserved using advanced segmentation techniques and the volumes were measured by summing the volumes of all voxels belonging to a particular tissue class. The associations between volumetric brain MRI measures with motor behavior were explored using linear regression analyses. Results showed that larger total brain volumes were associated with higher motor score. Similar relationships were documented for parietal lobe, deep gray matter (GM) and cerebellum volumes. Volumetric quantitative data of brain structures may serve as biomarkers for subtle motor deficits described in very preterm born infants without or with mild brain lesions apparent on MRI.

Preterm infants ; Neurodevelopment ; Motor behavior ; Magnetic resonance imaging ; Volumetric measurements ; Infant Motor Profile

nije evidentirano