Detection of novel and confirmation of very rare and rare HLA alleles by next generation sequencing in Croatia (CROSBI ID 278901)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Burek Kamenaric, Marija ; Maskalan, Marija ; Grubic, Zorana ; Stingl Jankovic, Katarina ; Zunec, Renata
engleski
Detection of novel and confirmation of very rare and rare HLA alleles by next generation sequencing in Croatia
Routine HLA typing in clinical practice encompassing solid organ and hematopoietic stem cells transplantation programs, disease association typing, volunteer marrow donor typing and population studies, provided a large dataset for studying HLA allele polymorphism in the Croatian population which led to the identification of new, very rare and rare HLA alleles. Over the last 4 years we have identified six new HLA alleles (HLA-A*01:200, A*02:836, A*11:01:01:44, B*08:251, B*18:169 and C*05:46:01:02) and a number of very rare (HLA-B*08:78, DRB1*12:39, DRB1*13:23:02 and DQB1*06:09:04) or rare (HLA-A*24:41, B*39:40:01N, B*51:78:01, DRB1*01:31 and DRB1*14:111) alleles using sequence-based typing methods. The reported data enhance the knowledge about HLA polymorphisms in the Croatian population and provide a foundation for further studies in population genetics.
Croatia, HLA haplotypes, NGS, novel HLA alleles, very rare HLA alleles
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Podaci o izdanju
Povezanost rada
Biologija, Kliničke medicinske znanosti