engleski

Solid-state study of the structure and host– guest chemistry of α- and β-cyclodextrin- ferrocene inclusion complexes

It has been recently shown that N-alkylated ferrocene quinoline conjugates exhibited inhibitory effects on selected tumor cell lines. Similar biological activity has been demonstrated by ferrocene thymine conjugates. However, their application is limited, due to the high lipophilicity of these compounds and the poor solubility in water. Therefore, to solve these obstacle inclusion complexes with cyclodextrin have proved to be useful because they allow better solubility in water, and thus better bio-distribution and pharmacokinetic properties of some drugs. The formation of inclusion complex of ferrocene derivatives with α- and β-cyclodextrin was carried out mechanochemical by ball‐milling. The solid- state grinding approach to preparing complexes is a newer method within green chemistry approach that draws great attention. Host-guest complexation in the solid state was studied and characterized by NMR spectroscopy, IR and X-ray powder diffraction.

Ferrocene ; Mechanochemistry ; Beta-cyclodextrin

nije evidentirano