engleski

Prevalence of 25-hydroxycholecalciferol deficiency and metabolic syndrome in Croatian women with newly diagnosed breast cancer

Aim of this study was to determine the prevalence of vitamin D deficiency (VDD) and metabolic syndrome (MetS), including individual MetS components, in Croatian women with newly diagnosed breast cancer (BC), exploring differences by the menopausal status. This cross-sectional, observational study recruited 203 adult female patients with newly diagnosed BC of any stage from all Croatian regions (median age 59 years ; range 28-87), hospitalized consecutively for their first treatment between December 2016 and August 2017. We analyzed pretreatment fasting serum concentrations of 25-hydroxycholecalciferol (25(OH)D), high density lipoprotein, low density lipoprotein, triglycerides, plasma glucose and measured systolic and diastolic blood pressure, weight and waist circumference ; defining VDD as 25(OH)D concentrations <50 nmol/L and MetS according to 2006 International Diabetes Federation consensus. Consistency of the results was explored by sampling periods, regions and size of settlements. In total sample, 28.6% of patients presented with concomitant VDD+MetS, whilst VDD was found in 55.1% of women (finding was consistent by menopausal status), and 48.3% had MetS (65.4% of postmenopausal vs 15.7% of premenopausal women). Concomitant VDD+MetS was more frequent in continental region (P=0.043), and VDD in continental postmenopausal women (P=0.024), while in premenopausal women VDD was more frequent during winter period (P=0.038). In conclusion, high prevalence of VDD and MetS were found in newly diagnosed BC patients, with some regional and seasonal differences.

breast cancer ; vitamin D ; 25-hydroxycholecalciferol ; deficiency ; metabolic syndrome ; Croatia

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