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Pregled bibliografske jedinice broj: 1060772

Extended-spectrum beta-lactamases and plasmid diversity in urinary isolates of Escherichia coli in Croatia: a nation-wide, multicentric, retrospective study


Krilanović, Marija; Tomić-Paradžik, Maja; Meštrović, Tomislav; Beader, Nataša; Herljević, Zoran; Conzemius, Rick; Barišić, Ivan; Vraneš, Jasmina; Elveđi-Gašparović, Vesna; Bedenić, Branka
Extended-spectrum beta-lactamases and plasmid diversity in urinary isolates of Escherichia coli in Croatia: a nation-wide, multicentric, retrospective study // Folia microbiologica, Epub ahead of print (2020), [10.1007/s12223-019-00769-1]; PMID: 31953747, 19 doi:0.1007/s12223-019-00769-1 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1060772 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Extended-spectrum beta-lactamases and plasmid diversity in urinary isolates of Escherichia coli in Croatia: a nation-wide, multicentric, retrospective study

Autori
Krilanović, Marija ; Tomić-Paradžik, Maja ; Meštrović, Tomislav ; Beader, Nataša ; Herljević, Zoran ; Conzemius, Rick ; Barišić, Ivan ; Vraneš, Jasmina ; Elveđi-Gašparović, Vesna ; Bedenić, Branka

Izvornik
Folia microbiologica (0015-5632) Epub ahead of print (2020), [10.1007/s12223-019-00769-1]; PMID: 31953747, 19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CTX-M beta-lactamase type ; E. coli ; ESBL ; Plasmid ; Urinary tract infection

Sažetak
In recent years, a dramatic increase in the prevalence of Escherichia coli strains producing extended-spectrum β-lactamases (ESBLs) has been observed - both in the community and in healthcare settings. This multicentric study aimed to characterize ESBLs produced by E. coli isolates causing hospital- onset and community urinary tract infections, as well as to compare their antimicrobial sensitivity patterns, β-lactamase content and plasmid types. Phenotypic tests for the detection of ESBLs and plasmid-mediated AmpC β- lactamases were initially pursued, followed by molecular detection of resistance genes, plasmid characterization, genotyping with pulsed-field gel electrophoresis and whole genome sequencing (WGS). The isolates exhibited high level of resistance to expanded-spectrum cephalosporins (ESC) and carried CTX-M (cefotaximase-Munich) or TEM (Temoniera) β- lactamases. All six representative isolates subjected to WGS belonged to the widespread clone ST131. In conclusion, our study demonstrated dissemination of group 1 CTX-M positive E. coli in different geographic regions of Croatia, but also different components of the health care systems (hospitals, nursing homes and the community) and confirmed the switch from SHV-2 (suphydril variant) and SHV-5 ESBLs to the nation-wide predominance of group 1 CTX-M β-lactamases. Different plasmids were shown to be associated with the dissemination of blaCTX-M genes in different geographic regions of Croatia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek

Citiraj ovu publikaciju

Krilanović, Marija; Tomić-Paradžik, Maja; Meštrović, Tomislav; Beader, Nataša; Herljević, Zoran; Conzemius, Rick; Barišić, Ivan; Vraneš, Jasmina; Elveđi-Gašparović, Vesna; Bedenić, Branka
Extended-spectrum beta-lactamases and plasmid diversity in urinary isolates of Escherichia coli in Croatia: a nation-wide, multicentric, retrospective study // Folia microbiologica, Epub ahead of print (2020), [10.1007/s12223-019-00769-1]; PMID: 31953747, 19 doi:0.1007/s12223-019-00769-1 (međunarodna recenzija, članak, znanstveni)
Krilanović, M., Tomić-Paradžik, M., Meštrović, T., Beader, N., Herljević, Z., Conzemius, R., Barišić, I., Vraneš, J., Elveđi-Gašparović, V. & Bedenić, B. (2020) Extended-spectrum beta-lactamases and plasmid diversity in urinary isolates of Escherichia coli in Croatia: a nation-wide, multicentric, retrospective study. Folia microbiologica, Epub ahead of print ([10.1007/s12223-019-00769-1]), PMID: 31953747, 19 doi:0.1007/s12223-019-00769-1.
@article{article, year = {2020}, pages = {19}, DOI = {0.1007/s12223-019-00769-1}, chapter = {PMID: 31953747}, keywords = {CTX-M beta-lactamase type, E. coli, ESBL, Plasmid, Urinary tract infection}, journal = {Folia microbiologica}, doi = {0.1007/s12223-019-00769-1}, volume = {Epub ahead of print}, number = {[10.1007/s12223-019-00769-1]}, issn = {0015-5632}, title = {Extended-spectrum beta-lactamases and plasmid diversity in urinary isolates of Escherichia coli in Croatia: a nation-wide, multicentric, retrospective study}, keyword = {CTX-M beta-lactamase type, E. coli, ESBL, Plasmid, Urinary tract infection}, chapternumber = {PMID: 31953747} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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