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Pregled bibliografske jedinice broj: 1060166

Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3


Dragojević, Jelena; Marić, Petra; Lončar, Jovica; Popović, Marta; Mihaljević, Ivan; Smital, Tvrtko
Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3 // Comparative biochemistry and physiology. C. Toxicology & pharmacology, 231 (2020), 108742, 8 doi:10.1016/j.cbpc.2020.108742 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1060166 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3

Autori
Dragojević, Jelena ; Marić, Petra ; Lončar, Jovica ; Popović, Marta ; Mihaljević, Ivan ; Smital, Tvrtko

Izvornik
Comparative biochemistry and physiology. C. Toxicology & pharmacology (1532-0456) 231 (2020); 108742, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Oat1 and Oat3 transporters ; zebrafish ; stable transfectants ; environmental contaminants ; interaction screening ; cytotoxicity

Sažetak
Organic anion transporters (OATs) are transmembrane proteins which belong to SLC22 subfamily. They are responsible for the uptake of various endo- and xenobiotics into the cells of different organs and tissues. Following our previous work on characterization of zebrafish Oat1 and Oat3, in this study we analyzed interaction of various classes of environmental contaminants with these membrane transporters using the transport activity assay with HEK293 Flp-In cell line stably overexpressing zebrafish Oat1 and Oat3, respectively. Based on the initial screening of a series of 36 environmental contaminants on their ability to interact with zebrafish Oat1 and Oat3, the most potent interactors were selected, their IC50 values calculated and type of interaction determined. Finally, to further confirm the type of interaction and initially evaluate their toxic potential, the cytotoxicity assays were performed. Broad ligand selectivity and similarity of zebrafish Oat1 and Oat3 with mammalian orthologs was confirmed and potent interactors among environmental contaminants identified.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Dragojević, Jelena; Marić, Petra; Lončar, Jovica; Popović, Marta; Mihaljević, Ivan; Smital, Tvrtko
Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3 // Comparative biochemistry and physiology. C. Toxicology & pharmacology, 231 (2020), 108742, 8 doi:10.1016/j.cbpc.2020.108742 (međunarodna recenzija, članak, znanstveni)
Dragojević, J., Marić, P., Lončar, J., Popović, M., Mihaljević, I. & Smital, T. (2020) Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3. Comparative biochemistry and physiology. C. Toxicology & pharmacology, 231, 108742, 8 doi:10.1016/j.cbpc.2020.108742.
@article{article, year = {2020}, pages = {8}, DOI = {10.1016/j.cbpc.2020.108742}, chapter = {108742}, keywords = {Oat1 and Oat3 transporters, zebrafish, stable transfectants, environmental contaminants, interaction screening, cytotoxicity}, journal = {Comparative biochemistry and physiology. C. Toxicology and pharmacology}, doi = {10.1016/j.cbpc.2020.108742}, volume = {231}, issn = {1532-0456}, title = {Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3}, keyword = {Oat1 and Oat3 transporters, zebrafish, stable transfectants, environmental contaminants, interaction screening, cytotoxicity}, chapternumber = {108742} }
@article{article, year = {2020}, pages = {8}, DOI = {10.1016/j.cbpc.2020.108742}, chapter = {108742}, keywords = {Oat1 and Oat3 transporters, zebrafish, stable transfectants, environmental contaminants, interaction screening, cytotoxicity}, journal = {Comparative biochemistry and physiology. C. Toxicology and pharmacology}, doi = {10.1016/j.cbpc.2020.108742}, volume = {231}, issn = {1532-0456}, title = {Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3}, keyword = {Oat1 and Oat3 transporters, zebrafish, stable transfectants, environmental contaminants, interaction screening, cytotoxicity}, chapternumber = {108742} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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