Organocatalytic Synthesis of α,α–Diaryl Substituted α–Amino Acid Derivatives by an Interrupted Three-Component Ugi Reaction (CROSBI ID 278125)
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Glavač, Danijel ; Jerić, Ivanka ; Gredičak, Matija
engleski
Organocatalytic Synthesis of α,α–Diaryl Substituted α–Amino Acid Derivatives by an Interrupted Three-Component Ugi Reaction
An organocatalytic interrupted three-component Ugi reaction for the synthesis of α, α–diaryl α– amino acid derivatives is described. The transformation proceeds with a range of isocyanides and 3-aryl isoindolinone alcohols using Brønsted acid catalysts to afford products in good to excellent yields. Based on the obtained results, a reaction mechanism is proposed and discussed.
organocatalytic synthesis ; α, α–disubstituted amino acids ; Ugi reaction
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