engleski

Functionalized magnetite nanoparticles for drug loading, release, and delivery of poorly soluble active biomolecules

Nanotechnology provides smart materials for drug delivery, prognosis, and treatment for diseases. The drug applications of nanoparticles as drug carriers allows improved localizations of the therapeutics on the target site. Metal or metal oxide nanoparticles such as superparamagnetic iron oxides nanoparticles are most commonly used as drug carriers. These nanoparticles are nontoxic, biodegradable and biocompatible. Magnetite nanoparticles emerge as the ones having effectively controlled particle size and surface chemistry, enhanced permeation, flexibility, solubility and release of therapeutically active agents to attain the target and specific activity at a predetermined rate and time. The intention was to use the flavonoid loaded clusters of magnetite nanoparticles as vectors that can be directed using a magnetic field gradient towards a certain location. Loading of poorly soluble, hydrophobic flavonoid onto mesoporous clusters comprised of coated PEG magnetite nanoparticles and their release under the influence of permanent and/or alternating magnetic field was investigated. [ref. 1]. A structural and morphological characterizations of magnetite nanoparticles have been performed by means scanning electron microscopy (SEM) and X-ray diffraction (XRPD). This research aimed to circumvent the problems of flavonoid stability and low solubility by their incorporation in the mesoporous nanoparticles, which should result in an alternative therapeutic approach for neurodegenerative diseases such as Alzheimer disease. The results of our experimental investigation confirmed that the mesoporous magnetite nanoparticles present a universal, stable and excellent drug carries particularly able to load and release with higher efficiency flavonoids of different physicochemical and/or structural properties.

magnetic nanoparticles ; flavonoids ; scanning electron microscopy

nije evidentirano