engleski

Antibiotic Resistance in Pharmaceutical Industry Effluents and Effluent-Impacted Environments

Overuse and misuse of antibiotics are likely the leading causes of antibiotic resistance accumulation in human pathogens, but it has in the last decade been recognized that the discharges from antibiotic manufacturing facilities can also contribute. Such discharges have repeatedly been shown to provide conditions where antibiotics reach concentrations that are selective for resistance enrichment. Manufacturing facilities and environments receiving their effluents are, therefore, key to determining the magnitude of antibiotic resistance, as well as identifying the critical control points to slow its emergence and spread. This chapter endeavours to review the recent research in the extent of pollution from antibiotic-producing factories and the effects of this pollution in the external environment. It also provides a case study in Croatia summarizing the discharges from the manufacturing of the antibiotic azithromycin and the subsequent impact these discharges caused to the receiving river.

antibiotic resistance ; environmental pollution ; manufacturing ; pharmaceutical effluent

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