Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1059876

HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia.


Grubor, Mirko; Živković, Maja; Šagud, Marina; Nikolac Perković, Matea; Mihaljević-Peleš, Alma; Pivac, Nela; Muck-Šeler, Dorotea; Švob Štrac, Dubravka
HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia. // International journal of molecular sciences, 21 (2020), 7; 2345, 15 doi:10.3390/ijms21072345 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1059876 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia.

Autori
Grubor, Mirko ; Živković, Maja ; Šagud, Marina ; Nikolac Perković, Matea ; Mihaljević-Peleš, Alma ; Pivac, Nela ; Muck-Šeler, Dorotea ; Švob Štrac, Dubravka

Izvornik
International journal of molecular sciences (1422-0067) 21 (2020), 7; 2345, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
schizophrenia ; haloperidol ; acute extrapyramidal side effects ; serotonin receptors ; gene polymorphisms ; HTR1B gene polymorphism ; akathisia

Sažetak
Schizophrenia is a serious, chronic psychiatric disorder requiring lifelong treatment. Extrapyramidal side effects (EPS) are common adverse reactions to antipsychotic medications. In addition to the dopaminergic system, serotonergic mechanisms, including serotonin (5-HT) receptors, might be involved in EPS development. This study aimed to examine molecular associations of HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms with acute EPS in 229 male schizophrenia patients, following two weeks of haloperidol monotherapy. The Simpson–Angus Rating Scale for Extrapyramidal Side Effects (SAS), Barnes Akathisia Rating Scale (BARS) and Extrapyramidal Symptom Rating Scale (ESRS) were used to evaluate EPS severity. Genotyping was performed using real-time PCR, following extraction of blood DNA. Significant acute EPS appeared in 48.03% of schizophrenia patients. For the rs13212041 HTR1B gene polymorphism, affecting microRNA regulation of HTR1B gene expression, a higher frequency of TT carriers was found among haloperidol-treated patients with akathisia when compared to the group without akathisia symptoms. In comparison to C-allele carriers, patients carrying the TT genotype had higher akathisia severity, as determined by the SAS, BARS and ESRS scales. These molecular findings suggest potential involvement of 5-HT1B receptors in akathisia development following haloperidol treatment, as well as possible epigenetic mechanisms of serotonergic modulation associated with antipsychotic-induced EPS.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Grubor, Mirko; Živković, Maja; Šagud, Marina; Nikolac Perković, Matea; Mihaljević-Peleš, Alma; Pivac, Nela; Muck-Šeler, Dorotea; Švob Štrac, Dubravka
HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia. // International journal of molecular sciences, 21 (2020), 7; 2345, 15 doi:10.3390/ijms21072345 (međunarodna recenzija, članak, znanstveni)
Grubor, M., Živković, M., Šagud, M., Nikolac Perković, M., Mihaljević-Peleš, A., Pivac, N., Muck-Šeler, D. & Švob Štrac, D. (2020) HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia.. International journal of molecular sciences, 21 (7), 2345, 15 doi:10.3390/ijms21072345.
@article{article, year = {2020}, pages = {15}, DOI = {10.3390/ijms21072345}, chapter = {2345}, keywords = {schizophrenia, haloperidol, acute extrapyramidal side effects, serotonin receptors, gene polymorphisms, HTR1B gene polymorphism, akathisia}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms21072345}, volume = {21}, number = {7}, issn = {1422-0067}, title = {HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia.}, keyword = {schizophrenia, haloperidol, acute extrapyramidal side effects, serotonin receptors, gene polymorphisms, HTR1B gene polymorphism, akathisia}, chapternumber = {2345} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati