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HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia. (CROSBI ID 278011)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Grubor, Mirko ; Živković, Maja ; Šagud, Marina ; Nikolac Perković, Matea ; Mihaljević-Peleš, Alma ; Pivac, Nela ; Muck-Šeler, Dorotea ; Švob Štrac, Dubravka HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia. // International journal of molecular sciences, 21 (2020), 7; 2345, 15. doi: 10.3390/ijms21072345

Podaci o odgovornosti

Grubor, Mirko ; Živković, Maja ; Šagud, Marina ; Nikolac Perković, Matea ; Mihaljević-Peleš, Alma ; Pivac, Nela ; Muck-Šeler, Dorotea ; Švob Štrac, Dubravka

engleski

HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia.

Schizophrenia is a serious, chronic psychiatric disorder requiring lifelong treatment. Extrapyramidal side effects (EPS) are common adverse reactions to antipsychotic medications. In addition to the dopaminergic system, serotonergic mechanisms, including serotonin (5-HT) receptors, might be involved in EPS development. This study aimed to examine molecular associations of HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms with acute EPS in 229 male schizophrenia patients, following two weeks of haloperidol monotherapy. The Simpson–Angus Rating Scale for Extrapyramidal Side Effects (SAS), Barnes Akathisia Rating Scale (BARS) and Extrapyramidal Symptom Rating Scale (ESRS) were used to evaluate EPS severity. Genotyping was performed using real-time PCR, following extraction of blood DNA. Significant acute EPS appeared in 48.03% of schizophrenia patients. For the rs13212041 HTR1B gene polymorphism, affecting microRNA regulation of HTR1B gene expression, a higher frequency of TT carriers was found among haloperidol-treated patients with akathisia when compared to the group without akathisia symptoms. In comparison to C-allele carriers, patients carrying the TT genotype had higher akathisia severity, as determined by the SAS, BARS and ESRS scales. These molecular findings suggest potential involvement of 5-HT1B receptors in akathisia development following haloperidol treatment, as well as possible epigenetic mechanisms of serotonergic modulation associated with antipsychotic-induced EPS.

schizophrenia ; haloperidol ; acute extrapyramidal side effects ; serotonin receptors ; gene polymorphisms ; HTR1B gene polymorphism ; akathisia

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Podaci o izdanju

21 (7)

2020.

2345

15

objavljeno

1422-0067

10.3390/ijms21072345

Trošak objave rada u otvorenom pristupu

Povezanost rada

Temeljne medicinske znanosti

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