Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma (CROSBI ID 277998)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Cumbo, Marija ; Tomić, Branko ; Dunjić, Sofija ; Jovanović, Tamara ; Gvozdenov, Maja ; Pruner, Iva ; Aralica, Gorana ; Kapitanović, Sanja ; Čačev, Tamara ; Đorđević, Valentina
hrvatski
Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma
Background/ Aim: Thrombin plays significant roles in various types of cancer. However, the expression levels of prothrombin, the thrombin precursor, in cancer remain unclear. Variants of the 3'end of the prothrombin gene lead to increased prothrombin expression. This study aimed to analyze prothrombin 3'end gene variants in colon tumor and adjacent normal tissue samples. Materials and Methods: The study group consisted of 93 patients suffering from colon adenocarcinoma. The 3'end of the prothrombin gene was analyzed by DNA sequencing. Results: Three variants, all previously associated with increased prothrombin expression were detected. Frequency of the FII 19911G allele was 46.77% and 47.85% in tumor and normal tissue, respectively. For the FII 20210A allele, the detected frequencies were 2.15% and 1.61%, respectively. The frequency of the FII c.1824T allele was 0.54% in both tissues. Four patients showed different genotypes in tumor and normal tissue. Conclusion: Prothrombin 3' end gene variants may play a role in colorectal cancer.
colon adenocarcinoma ; normal adjacent tissue ; prothrombin ; tumor ; 3'end gene variants
Rad je rezultat suradnje na bilateralnom projektu Uloga protrombina u karcinomu debelog crijeva.
engleski
Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma
nije evidentirano
colon adenocarcinoma ; normal adjacent tissue ; prothrombin ; tumor ; 3'end gene variants
nije evidentirano
Podaci o izdanju
39 (11)
2019.
6067-6071
objavljeno
0250-7005
1791-7530
10.21873/anticanres.13814
Povezanost rada
Temeljne medicinske znanosti