Characteristics of treatment and outcome in elderly patients with brain glioblastoma: a retrospective analysis of case series (CROSBI ID 277876)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Dobran, Mauro ; Nasi, D ; Constanza, MD ; Gladi, M ; Iacoangeli, M ; Rotim, Krešimir ; Splavski, Bruno
engleski
Characteristics of treatment and outcome in elderly patients with brain glioblastoma: a retrospective analysis of case series
Treatment modalities affecting quality of life and survival in elderly brain glioblastoma patients are not well defined. A single- institution data were analyzed during a 3-year period to disclose prognostic difference in management related to age. Karnofsky Performance Scale (KPS), overall survival (OS), and adjuvant therapy were evaluated. The case group comprised of elderly patients (>75 years), while the control group included those of younger age (<65 years). The investigated variables were correlated between the groups. Twenty elderly patients and a corresponding number of younger ones were analyzed. Preoperative KPS >70 indicated longer overall survival. Statistically significant correlation was recorded in both the control (p=0.036) and case (p=0.0053) groups. Lower postoperative KPS was significantly correlated with shorter OS in elderly patients (p=0.023). The correlation between the extent of tumor resection and OS was statistically significant in younger patients only (p=0.04). Overall survival was significantly shorter in elderly patients regardless of the extent of tumor resection (p=0.0057). Adjuvant therapy was significantly associated with longer OS in both the case (p=0.032) and control (p=0.013) groups. Elderly population is a more endangered group of surgical brain glioblastoma patients having lower quality of life and shorter overall survival. The management protocol should be personalized for each individual case in this age group of patients to reduce postoperative complications and grant a satisfactory quality of life. © 2019, Klinicka Bolnica Sestre Milosrdnice. All rights reserved.
elderly patients ; glioblastoma ; management outcome ; prognosis ; treatment modalities
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Podaci o izdanju
58 (2)
2019.
221-228
objavljeno
0353-9466
1333-9451
10.20471/acc.2019.58.02.04
Povezanost rada
Kliničke medicinske znanosti