engleski

The association of salivary parameters with the severity of obstructive sleep apnea

Salivary parameters may offer a noninvasive and easy sampling alternative in diagnosis and monitoring high risk behaviour and disease progresion. The aim of this study is to establish association of salivary flow rate, salivary pH, salivary calcium, phosphate and magnesium levels with the severity of obstructive sleep apnea (OSA). Materials and methods: The study involved 138 subject who were grouped according to the severity of OSA: 10 subject served as controls, 78 subjects had mild to moderate OSA and 50 had severe OSA. Unstimulated saliva was collected from all subjects and they had completed a questionnaire for evaluating the subjective assessment of dry mouth. Salivary pH was measured immediately after collection with pH tester of ±0.01accuracy. Ca, P, Mg levels were measured with inductively coupled plasma mass spectrometry (ICP-MS). Results: There was significant correlation between salivary flow rate and the severity of OSA. The subject with severe OSA had higher salivary flow rate than subjects with mild to moderate OSA (3, 97±2, 59 vs 4, 95±2, 83, p=0, 046). Furthermore, the prevalence of subjective assessment of dry mouth upon awakening was higher in subjects with severe OSA than in subjects with mild to moderate OSA (p=0, 023). There were no significant differences in salivary calcium, phosphate and magnesium levels between subject groups. Conlusion: Based on the study results indicate that severe OSA subjects had higher salivary flow rate compared to mild and moderate OSA subjects. However, subjective assessment of dry mouth upon awakening appears to be significantly associated with severe OSA.

sleep apnea ; saliva

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