engleski

Natural course activity and complications of ulcerative colitis therapy compared to Chron's disease; results of the research study of inflammatory bowel disease in the area of Osijek-baranja county in the period 2000-2014

The increasing incidence of the last decades of Crohn's disease and ulcerative colitis in the world has sparked a different way of thinking about their cause and susceptibility.Laboratory data confirm that the disease is a result of a disturbed immune response in a genetic subject, and the first identified gene responsible for the development of Crohn's disease is NOD2/CARD15.The aim of this study was to put Crohn's disease and ulcerative colitis in relation to the occurrence of relapse, duration of remission, number of hospitalizations and number of surgical procedures.This research is part of the large project mentored by prof.dr.sc. A. Včev named "Prevalence of NOD2 and MDR1 polymorphisms among patients with inflammatory bowel disease in KBC Osijek and OB Našice in the period 2000-2014", which seeks out more attention to molecular biology in the medical compatibility model and genetics in their role as a modifier of clinical diseases.The results obtained through research within the project used in this publication are the results of the doctoral dissertation of the chief investigator M. Žulj, MD. MATERIALS AND METHODS: The research was based on medical documentation and conducting a survey of patients affected by inflammatory bowel disease, treated at the Department of gastroenerology at Clinical hospital Osijek and County hospital Našice. In total, 81 patients were involved, of which 52 of them were diagnosed with ulcerative colitis and 29 with Crohn's disease. RESULTS: Relapse occurred in 60 patients, alike in Crohn's disease and ulcerative colitis. Operative procedure was performed in 20 (24.7%) patients, significantly more frequent in Crohn's disease (Fisher's exact test, P <0.001). The majority of patients, 43 (54.4%), were hospitalized 1-3 times, with a great difference in number of times hospitalized between patients with Crohn's disease and those with ulcerative colitis (Fisher's exact test, P=0.07). Remission occured in 76 (95%) patients. In 39 (52%) patients last remission lasted from 1 to 5 years. CONCLUSION: Due to the nature of inflammatory bowel diseases, Crohn's disease and ulcerative colitis have similar occurence of relapse in patients and duration of remission, but differ in the number of hospitalizations and operative interventions.

inflammatory bowel disease ; ulcerative colitis ; Crohn's disease ; relapse ; remission

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