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Vitamin D Deficiency and Inflammation Activity in Crohn`s Disease at the Time of Diagnosis

Background: Vitamin D deficiency is often found in patients with IBD. Vitamin D has immunomodulatory activity avoiding excessive immune response and has the function of repairing the intestinal mucosal barrier in IBD. Patients and Methods: We have analyzed 20 patients with Crohn`s disease at the time of diagnosis. Patients received vitamin D supplementation with their standard therapy – corticosteroids and/or azathioprine .We measured vitamin D levels, sedimentation rate, CRP and calprotectin levels at the time of diagnosis and compared them to CDAI score. Results:There was 12 male and 8 female patients, average age of 34.12 +-. 60% of patients had vitamin D deficiency and 20% had vitamin D insufficiency. The mean CDAI was 286.12 +- 58.22. There was a correlation between CDAI and vitamin D deficiency (p= 0.63, p<0.05, Spearman rank correlation).Also we found correlation between calprotectin levels and vitamin D deficiency (p=0.50, p<0.05, Spearman rank correlation).Vitamin D levels are unrelated to sedimentation rate and CRP. Conclusion: Our study confirmed previous results about vitamin D deficiency and insufficiency being prevelent in IBD. Also, vitamin D defficiency is associated with higher calprotectin levels and CDAI suggesting its potential antiinflammatory role in intestinal tissue.

vitamin D, deficiency, inflamation, bowel, chron, disease

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