Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction (CROSBI ID 277603)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Laskarin, G. ; Persic, V. ; Ruzic, A. ; Miletic, B. ; Rakic, M. ; Samsa, D. Travica ; Raljevic, D. ; Pejcinovic, V. Pehar ; Miskulin, R. ; Rukavina, D.
engleski
Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction
The aim of this investigation was to examine the role of perforin (P)-mediated cytotoxicity in the dynamics of tissue damage in patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with anti-ischaemic drugs. We enrolled 48 patients with NSTEMI in this study [age, 71.5 years ; 61.5/76 (median, 25th/75th percentiles)]. The percentage of total peripheral blood P(+) lymphocytes was elevated owing to the increased frequency of P(+) cells within natural killer (NK) subsets, T and NKT cells in patients on day 1 after NSTEMI when compared with healthy controls. Positive correlations were found between cardiac troponin I plasma concentrations and the frequency of P(+) cells, P(+) T cells, P(+) NK cells and their CD56(+dim) and CD56(+bright) subsets during the first week after the NSTEMI. The expression of P in NK cells was accompanied by P-mediated cytotoxicity against K-562 targets at all days examined, except day 21, when an anti-perforin monoclonal antibody did not completely abolish the killing. The percentage of P(+) T cells, P(+) NKT cells and P(+) NK subsets was the highest on the day 1 after NSTEMI and decreased in the post- infarction period. CD56(+) lymphocytes were found in damaged myocardium, suggesting their tissue recruitment. In conclusion, patients with NSTEMI have a strong and prolonged P- mediated systemic inflammatory reaction, which may sustain autoaggressive reactions towards myocardial tissue during the development of myocardial infarction.
cytotoxicity ; lymphocyte ; myocardial infarction ; NSTEMI ; perforin
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Podaci o izdanju
74 (2)
2011.
195-204
objavljeno
0300-9475
10.1111/j.1365-3083.2011.02554.x
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti