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Pregled bibliografske jedinice broj: 1058326

Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development


Danolić, Damir; Heffer, Marija; Wagner, Jasenka; Škrlec, Ivana; Alvir, Ilija; Mamić, Ivica; Šušnjar, Lucija; Banović, Marija; Danolić, Danijela; Puljiz, Mario
Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development // Journal of obstetrics and gynaecology, 40 (2020), 8; 1127-1132 doi:10.1080/01443615.2019.1692801 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1058326 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development

Autori
Danolić, Damir ; Heffer, Marija ; Wagner, Jasenka ; Škrlec, Ivana ; Alvir, Ilija ; Mamić, Ivica ; Šušnjar, Lucija ; Banović, Marija ; Danolić, Danijela ; Puljiz, Mario

Izvornik
Journal of obstetrics and gynaecology (0144-3615) 40 (2020), 8; 1127-1132

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cervical cancer ; gangliosides ; genetic polymorphism ; genotype ; risk factor

Sažetak
Cervical cancer is the most common gynaecological cancer in women. Cell mediated immunity plays a significant role in the progression or regression of neoplastic cervical lesions caused by human papilloma virus infection. Engagement of antigen-specific T cell receptors is a prerequisite for T cell activation. The initial events of T cell activation involve the movement of the T cell receptor into specialised microdomains known as lipid rafts. Gangliosides play an active role in the formation, stabilisation and biological functions of lipid rafts. This study aims to determine whether polymorphisms in the genes involved in the biosynthesis of gangliosides represent risk a factor for cervical cancer. Taqman methods for single nucleotide polymorphism genotyping was used. All subjects carried the homozygous wild-type genotypes for all analysed genes (CC for gene B4GALT5, AA for gene ST3GAL5, AA for gene ST8SIA1 and CC for gene B4GALNT1). A χ2 test showed significant differences in genotype failure for B4GALT5 rs138960078 (χ2 = 32.02, df = 1, p = .001) and genotype failure for B4GALNT1 rs144643461 (χ2 = 41.03, df = 1, p = .001) between cervical cancer group and control group. Genotype failures were significantly more frequent in the cervical cancer group. Unknown adjacent SNPs to rs138960078 in gene B4GALT5 and rs144643461 in gene B4GALNT1 could be associated with cervical cancer development.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Medicinski fakultet, Osijek,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Profili:

Avatar Url Jasenka Wagner (autor)

Avatar Url Ivana Škrlec (autor)

Avatar Url Ilija Alvir (autor)

Avatar Url Marija Heffer (autor)

Avatar Url Mario Puljiz (autor)

Poveznice na cjeloviti tekst rada:

doi www.tandfonline.com

Citiraj ovu publikaciju:

Danolić, Damir; Heffer, Marija; Wagner, Jasenka; Škrlec, Ivana; Alvir, Ilija; Mamić, Ivica; Šušnjar, Lucija; Banović, Marija; Danolić, Danijela; Puljiz, Mario
Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development // Journal of obstetrics and gynaecology, 40 (2020), 8; 1127-1132 doi:10.1080/01443615.2019.1692801 (međunarodna recenzija, članak, znanstveni)
Danolić, D., Heffer, M., Wagner, J., Škrlec, I., Alvir, I., Mamić, I., Šušnjar, L., Banović, M., Danolić, D. & Puljiz, M. (2020) Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development. Journal of obstetrics and gynaecology, 40 (8), 1127-1132 doi:10.1080/01443615.2019.1692801.
@article{article, year = {2020}, pages = {1127-1132}, DOI = {10.1080/01443615.2019.1692801}, keywords = {cervical cancer, gangliosides, genetic polymorphism, genotype, risk factor}, journal = {Journal of obstetrics and gynaecology}, doi = {10.1080/01443615.2019.1692801}, volume = {40}, number = {8}, issn = {0144-3615}, title = {Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development}, keyword = {cervical cancer, gangliosides, genetic polymorphism, genotype, risk factor} }
@article{article, year = {2020}, pages = {1127-1132}, DOI = {10.1080/01443615.2019.1692801}, keywords = {cervical cancer, gangliosides, genetic polymorphism, genotype, risk factor}, journal = {Journal of obstetrics and gynaecology}, doi = {10.1080/01443615.2019.1692801}, volume = {40}, number = {8}, issn = {0144-3615}, title = {Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development}, keyword = {cervical cancer, gangliosides, genetic polymorphism, genotype, risk factor} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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